Systemic mastocytosis (SM) is a rare clinical condition resulting from a clonal proliferation of abnormal mast cells. The clinical presentation may vary from mild cutaneous manifestations to aggressive systemic symptoms including intermittent episodes of anaphylaxis. We present a case of a 69-year-old male with abrupt and recurrent episodes of anaphylaxis with refractory distributive shock following cardiac surgery with cardiopulmonary bypass. Following a complex postoperative course, a bone marrow biopsy ultimately confirmed the diagnosis. Although rare, SM should be considered in the differential diagnosis of postoperative patients with unexplained and recurrent episodes of distributive shock.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856421 | PMC |
| http://dx.doi.org/10.1213/XAA.0000000000001093 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Diagnostic Accuracy of Ultrasound in Intensive Care Patients with Undifferentiated Shock: A Systematic Review and Meta-analysis.
Indian J Crit Care Med
December 2024
Department of Intensive Care, St George Hospital, Kogarah, New South Wales, Australia.
Purpose: This systematic review aimed to assess the accuracy of ultrasound in diagnosing shock types among intensive care patients.
Materials And Methods: A comprehensive search of PubMed, Embase, Scopus, Cochrane Central Register, and Google Scholar was conducted for controlled trials published up to June 2023. Two intensivists independently screened articles for full-text reviews and abstracts, evaluating study quality using the QUADAS-2 tool.
Intestinal Pseudo-Obstruction After Vincristine Use.
Cureus
November 2024
Department of Intensive Care Medicine, Centro Hospitalar Universitário de São João, Porto, PRT.
A 73-year-old man presented with nausea, abdominal discomfort, and distention persisting for the past five days. He had previously been diagnosed with stage III peripheral CD4+ T cell lymphoma and had initiated chemotherapy comprising vincristine two weeks prior to presentation. An evaluation revealed diffuse colon distention and pneumatosis intestinalis without mechanical obstruction, consistent with acute colonic pseudo-obstruction.
View Article and Find Full Text PDFVasoactive Agents in Burn Patients - Perspectives on Angiotensin-II.
J Burn Care Res
December 2024
Regional One Health, Department of Pharmacy, Memphis, TN, USA.
Severe burn injury poses significant clinical challenges, often necessitating the use of vasoactive agents to maintain perfusion. This narrative review explores the current landscape of vasoactive agents in acute burn shock resuscitation and severe burn-injured patients who develop septic shock, with a particular focus on the potential role of the novel vasoactive agent, synthetic angiotensin-II (AT-II), in these settings. While catecholamines and vasopressin remain cornerstone therapies, adverse effects, variable patient response, and a new understanding of burn injury pathophysiology highlight the potentially evolving role of vasoactive agents in these clinical scenarios.
View Article and Find Full Text PDFCardiac Complications of Immune Checkpoint Inhibitors and Chimeric Antigen Receptor T Cell Therapy.
Cardiol Clin
February 2025
Division of Cardiology, Department of Internal Medicine, Lahey Hospital and Medical Center, 41 Mall Road, Burlington, MA 01805, USA; Department of Medicine (Research), Cardio-Oncology Program, Lahey Hospital and Medical Center, 41 Mall Road, Burlington, MA 01805, USA. Electronic address:
Article Synopsis
- - Immune checkpoint inhibitors and chimeric antigen receptor T-cell therapy have drastically improved cancer treatment but can lead to serious cardiovascular issues, notably myocarditis.
- - Diagnosis of ICI-myocarditis involves using a combination of biomarkers, imaging, and endomyocardial biopsy, while cytokine release syndrome (CRS) presents similar symptoms to distributive shock.
- - Effective management includes stopping the offending therapy, providing immunosuppression with corticosteroids for ICI-myocarditis, and using interleukin-6 antagonists for CRS, requiring close collaboration between oncologists and cardiologists for optimal care.
Outcomes of Pressure Ulcer Injuries Classified by Race: A 10-Year Nationwide Analysis.
Cureus
October 2024
Internal Medicine, South Shore University Hospital, Bay Shore, USA.
Article Synopsis
- The study aimed to assess the prevalence and impact of pressure ulcer injuries (PIs) in minority groups within U.S. hospitals, focusing on their association with long-term pressure on bony areas.
- Utilizing the National Inpatient Sample from 2011 to 2020, the researchers analyzed a total of 5,993,667 PI admissions and matching controls, comparing factors like age, gender, insurance type, and comorbidity levels.
- Findings revealed that male patients, older individuals (75+), and those on Medicare/Medicaid were more likely to develop PIs, with African Americans showing a higher risk compared to Whites and experiencing different rates of associated complications.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!