Tunicamycins, which are nucleoside natural products, inhibit both bacterial phospho--acetylmuraminic acid (MurNAc)-pentapeptide translocase (MraY) and human UDP--acetylglucosamine (GlcNAc): polyprenol phosphate translocase (GPT). The improved synthesis and detailed biological evaluation of an MraY-selective inhibitor, , where the GlcNAc moiety was modified to a MurNAc amide, has been described.
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