A convenient and efficient approach for the difunctionalization of alkenylpyridine -oxides through the tandem addition/Boekelheide rearrangement has been developed. The C-O and C-X (S, O, Cl) bonds are constructed simultaneously at the α- and β-positions under mild reaction conditions in 100% atom economy, which complements previously reported α- or β-functionalizations.
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Difunctionalization of Alkenylpyridine -Oxides by the Tandem Addition/Boekelheide Rearrangement.
Org Lett
October 2019
Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences , Sun Yat-sen University, Guangzhou 510006 , China.
A convenient and efficient approach for the difunctionalization of alkenylpyridine -oxides through the tandem addition/Boekelheide rearrangement has been developed. The C-O and C-X (S, O, Cl) bonds are constructed simultaneously at the α- and β-positions under mild reaction conditions in 100% atom economy, which complements previously reported α- or β-functionalizations.
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