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Sibanin, a novel black fly-derived Kunitz protease inhibitor, prevents thrombus formation in mice by anticoagulation-antiplatelet duality.
Int J Biol Macromol
January 2025
School of Basic Medical Sciences, Kunming Medical University, Kunming 650500, Yunnan, China. Electronic address:
Most Kunitz inhibitors exhibit serine protease inhibitory activity, but limited information is available on the regulation of platelet function. Herein, we report the purification and characterization of a novel single Kunitz domain inhibitor (Sibanin) from the salivary glands of the black fly Simulium bannaense. Recombinant Sibanin prolonged activated partial thromboplastin time and prothrombin time, and exhibited high-affinity binding to FXa and elastase with a KD of 5.
View Article and Find Full Text PDFRed cell microparticles produced using high-pressure extrusion enhance both primary and secondary hemostasis.
Pharmacol Rep
January 2025
Department of Neurology, Peritz Scheinberg Cerebral Vascular Disease Research Laboratories, University of Miami Miller School of Medicine, 1600 NW 10th Ave RMSB #7046, Miami, FL, 33136, USA.
Background: Current therapies to treat excessive bleeding are associated with significant complications, which may outweigh their benefits. Red blood cell-derived microparticles (RMPs) are a promising hemostatic agent. Previous studies demonstrated that they reduce bleeding in animal models, correct coagulation defects in patient blood, and have an excellent safety profile.
View Article and Find Full Text PDFExploring the morphine-platelet activity association in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention.
Platelets
December 2024
Department of Cardiology, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
Article Synopsis
- STEMI is typically triggered by a ruptured plaque, leading to blood clot formation, and treatments like platelet inhibitors and PCI are crucial for recovery.
- This study, part of the VALIDATE-SWEDHEART trial, analyzed 89 STEMI patients to examine how morphine, used for pain relief, affects platelet activity after treatment with ticagrelor and primary PCI.
- Results indicated that morphine treatment was associated with higher platelet aggregation one hour after PCI, but did not impact inflammation biomarkers or show significant differences before or twelve hours post-PCI.
A randomized, double-blind, placebo controlled study to evaluate the effect of alpha-lipoic acid on inhibition of ADP-and collagen-induced platelet aggregation ex vivo in diabetic neuropathy patients on gabapentin or pregabalin.
J Postgrad Med
October 2024
Department of Clinical Pharmacology and Therapeutics, NIMS, Hyderabad, Telangana, India.
Background: Diabetic peripheral neuropathy (DPN) is a chronic microvascular complication in diabetic mellitus patients due to chronic hyperglycemia, resulting in platelet hyperactivity and dyslipidemia. Alpha-lipoic acid (ALA) is a potent antioxidant which has antiplatelet activity and lipid-modulating characteristics and plays a major role in the prevention of disease progression.
Aim: To evaluate the effect of ALA on inhibition of platelet aggregation and lipid profile.
Functional characterization of a nanobody-based glycoprotein VI-specific platelet agonist.
Res Pract Thromb Haemost
October 2024
Center for Benign Haematology, Thrombosis and Haemostasis, Van Creveldkliniek, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Background: Glycoprotein (GP)VI is a platelet-specific collagen receptor required for platelet activation during hemostasis. Platelet reactivity toward collagen is routinely assessed during diagnostic workup of platelet disorders. GPVI can be activated by inducing receptor clustering with suspensions of fibrillar collagen or synthetic cross-linked collagen-related peptide (CRP-XL).
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