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Low back pain (LBP) affects many individuals worldwide. The established association between LBP and spine motor control has led to the development of many control assessment techniques. To understand spine control and LBP, it is essential to know the relationship between assessment techniques. Systems identification (SI) and local dynamic stability (LDS) are two methods of quantifying spine control. SI provides a detailed description of control but uses linearity assumptions, whereas LDS provides a "black box" non-linear assessment during dynamic movements. Therefore, the purpose of this project was to compare control outcomes of SI and LDS. 15 participants completed two tasks (SI and LDS) in a random order. For the SI task, participants were seated and ventrally perturbed at the 10th thoracic vertebrae. They were instructed to resist the perturbations (resist condition) or to relax the trunk (relax condition). Admittance was computed, and a neuromuscular control model quantified lumbar stiffness, damping and muscle spindle feedback gains. For the LDS task, participants completed three repetitive movement blocks consisting of flexion/extension, axial rotation, and complex movements. In each block, the maximum finite-time Lyapunov exponent (λ) was estimated. A stepwise linear regression determined that λ during the rotation task was best predicted by SI outcomes in the relax condition (adjusted R = 0.83). Many conditions demonstrated no relationship between λ and SI outcomes. These findings outline the importance of a consistent framework for the assessment of spine control. This could clarify research comparisons and the understanding of the cause/effect role of LBP on spine control.
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http://dx.doi.org/10.1016/j.jbiomech.2019.109344 | DOI Listing |
Neurosci Lett
March 2025
Department of Organ Anatomy, Tohoku University Graduate School of Medicine, Sendai, Japan. Electronic address:
Fatty acid-binding protein 4 (FABP4), a key regulator of lipid metabolism and inflammation, has been implicated in neurodevelopmental disorders, including autism spectrum disorder (ASD). This study investigated the effects of FABP4 inhibition during gestation and lactation on offspring neurodevelopment using the selective FABP4 inhibitor BMS309403. Female mice received BMS309403 (15 mg/kg) via oral gavage from two weeks before mating to postnatal day 28 (P28).
View Article and Find Full Text PDFEBioMedicine
March 2025
Hunan Key Laboratory of Vascular Biology and Translational Medicine, Medical School, Hunan University of Chinese Medicine, Changsha, Hunan, China. Electronic address:
Background: Chromosome 16p11.2 is one of the most significant loci in the genome-wide association studies (GWAS) of schizophrenia. Despite several integrative analyses and functional genomics studies having been carried out to identify possible risk genes, their impacts in the pathogenesis of schizophrenia remain to be fully characterized.
View Article and Find Full Text PDFEur J Orthop Surg Traumatol
March 2025
Osaka Metropolitan University, Osaka, Japan.
Background: In the 2015 guidelines for the prevention and treatment of osteoporosis in Japan, the young adult mean percentage (%YAM) of the lumbar spine or femoral neck is required to diagnose osteoporosis in patients with distal radius fracture (DRF). When the %YAM of multiple locations is measured, the lower %YAM is adopted for the diagnosis. If the area with a lower %YAM is known, bone mineral densitometry tests may only need to be performed at one site.
View Article and Find Full Text PDFJ Neurosci
March 2025
Department of Anatomy, Faculty of Medicine, Hokkaido University, Sapporo 060-8638, Japan.
The endoplasmic reticulum (ER) is the largest intracellular Ca store, serving as the source and sink of intracellular Ca The ER Ca store is continuous yet organized into distinct subcompartments with spatial and functional heterogeneity. In cerebellar Purkinje cells (PCs), glutamatergic inputs trigger Ca release from specific ER domains via inositol 1,4,5-trisphosphate receptors (IPRs) or ryanodine receptors (RyRs). Upon ER store depletion, refilling occurs through store-operated Ca entry mediated by stromal interaction molecule-1 (STIM1).
View Article and Find Full Text PDFClin Neurol Neurosurg
March 2025
Vail-Summit Orthopaedics and Neurosurgery, 180 S Frontage Rd W, Suite 2700, Vail, CO 81657, United States.
Objectives: To implement an integrated anesthesia and surgery protocol of improved postoperative pain control to facilitate transitioning of minimally invasive transforaminal lumbar interbody fusion (MI-TLIF) from a hospital to an ambulatory surgery center setting by lowering postoperative (in-facility) narcotic consumption and length of stay (LOS) transitioning from general to awake spinal anesthesia.
Methods: A retrospective cohort study of 180 patients who received awake or general anesthesia (GA) MI-TLIF from 2017 to 2023.
Results: Among 180 MI-TLIF patients, 101 (56 %) received awake protocol and 79 (44 %) received general anesthesia.
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