AI Article Synopsis

  • * Researchers analyzed transcriptome data from 17 tissues across three family trios, identifying 62 genes with monoallelic expression in at least one tissue.
  • * The identified MAE genes are linked to important biological functions like gene regulation and immune responses, providing insights into how epigenetic factors contribute to the traits seen in Hanwoo cattle.

Article Abstract

The functional hemizygosity could be caused by the MAE of a given gene and it can be one of the sources to affect the phenotypic variation in cattle. We aimed to identify MAE genes across the transcriptome in Korean cattle (Hanwoo). For three Hanwoo family trios, the transcriptome data of 17 tissues were generated in three offspring. Sixty-two MAE genes had a monoallelic expression in at least one tissue. Comparing genotypes among each family trio, the preferred alleles of 18 genes were identified (maternal expression, n = 9; paternal expression, n = 9). The MAE genes are involved in gene regulation, metabolic processes, and immune responses, and in particular, six genes encode transcription factors (, , , , -, and ) with tissue-specific expression. In this study, we report genome-wide MAE genes in seventeen tissues of adult cattle. These results could help to elucidate epigenetic effects on phenotypic variation in Hanwoo.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826869PMC
http://dx.doi.org/10.3390/ani9100727DOI Listing

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