The article presents the results of the comprehensive hygienic studies of ambient air pollution (based on calculated and actual concentrations of main pollutants) in a zone of influence of modern filling stations (FS) of small and medium capacity, taking into account compliance with the fire-prevention requirements. Sanitary protection zones (SPZ) for filling stations were substantiated taking into account the capacity: for the filling stations of low and medium capacity - not less than 50 m, and for filling stations of large capacity - not less than 100 m at the equipping with the ecologically safe outfit, introduction of the effective air protection measures, and introduction of risk approach to sanitary-and-epidemiological assessment of the location of filling stations. Sanitary classification of the enterprises and industries was proved to require a revision and rationing of differentiated sanitary protection zones (minimum and maximum SPZ) for filling stations taking into account the capacity, implementation of the effective air protection measures and introduction of risk approach to sanitary- and-epidemiological assessment of the location of filling stations. A necessity of the introduction of the equipment to contain the carcinogenic fumes at vehicle refueling at existing and projected filling stations has been demonstrated, which will reduce air pollution in the working area for the filling stations workers and the environment of adjacent residential buildings, which will meet the EU directives (2008/50 / EC, 21.05, 2008; 2004/42 / EU, April 21, 2004; 1999/32 / EU, April 26, 1999; 98/70 / EU, May 21, 1998; 94/63 / EU, December 20, 1994) to the quality of gasoline, diesel fuel and control of the emissions from the filling stations, and the national legislation of Ukraine (SHR №173-96)..

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