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Gellan gum-based in-situ gel formulations for ocular drug delivery: A practical approach.
Int J Biol Macromol
December 2024
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha 761003, India. Electronic address:
Ophthalmic disorders significantly impact global health, affecting millions worldwide. Conventional treatments often face challenges related to poor bioavailability and short residence times on the ocular surface. In recent years, in-situ gels prepared using different natural gums including gellan gum has been investigated as a viable means of improving ocular medication delivery.
View Article and Find Full Text PDFMultivalent GCase Enhancers: Synthesis and Evaluation of Glyco-Gold Nanoparticles Decorated with Trihydroxypiperidine Iminosugars.
Bioconjug Chem
December 2024
Department of Chemistry "Ugo Schiff" (DICUS), University of Florence, Via della Lastruccia 3-13, Sesto Fiorentino, FI 50019, Italy.
The present study reports the preparation of the first multivalent iminosugars built onto a glyco-gold nanoparticle core (glyco-AuNPs) capable of stabilizing or enhancing the activity of the lysosomal enzyme GCase, which is defective in Gaucher disease. An -nonyltrihydroxypiperidine was selected as the bioactive iminosugar unit and further functionalized, via copper-catalyzed alkyne-azide cycloaddition, with a thiol-ending linker that allowed the conjugation to the gold core. These bioactive ligands were obtained with either a linear monomeric or dendritic trimeric arrangement of the iminosugar.
View Article and Find Full Text PDFMultivalent chitobiose self-assembled glycostructures as ligands to lysozyme.
Bioorg Chem
November 2024
Department of Organic Chemistry, Indian Institute of Science, Bangalore, India. Electronic address:
Article Synopsis
- * These structures can disassemble at different pH levels due to an ester linkage, and their ability to bind to lysozyme is influenced by the ratio of chitobiose in the mixture, showing higher binding affinity with increased chitobiose content.
- * The complex of chitobiose and lysozyme exhibits slower lytic activity compared to lysozyme alone, suggesting that while it binds strongly, it may delay the enzyme's effectiveness in breaking down bacteria.
Synthesis of a multivalent α-1,2-mannobiose ligand for targeting C-type lectins.
RSC Adv
November 2024
Department of Chemistry, Davidson College Davidson NC 28035 USA
The importance of lectins in biological processes such as pathogen recognition, cell adhesion, and cell recognition is well documented. C-Type lectins, which require calcium for binding, play an important role in the innate immune response by engaging carbohydrates presented as part of the human and pathogen glycocalyx. For example, lectins such as MBL, Dectin-2, langerin and DC-SIGN selectively recognize mannose rich (high-mannose) structures presented as part of the glycocalyx.
View Article and Find Full Text PDFConformation Influences Biological Fates of Peptide-Based Nanofilaments by Modulating Protein Adsorption and Interfilament Entanglement.
Adv Mater
November 2024
State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Filamentous structures exert biological functions mediated by multivalent interactions with their counterparts in sharp contrast with spherical ones. The physicochemical properties and unique behaviors of nanofilaments that are associated with multivalent interaction with protein are poorly understood. Here, peptide-based nanofilaments containing different homotetrapeptidic inserts are reported and their protein adsorption and biological fates are tested.
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