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Intracellular Delivery of Proteins by Protein-Recognizing Nanoparticles.
ACS Appl Mater Interfaces
January 2025
Department of Chemistry, Iowa State University, Ames, Iowa 50011-3111, United States.
Intracellular delivery of proteins can directly impact dysregulated and dysfunctional proteins and is a key step in the fast growing field of protein therapeutics. The vast majority of protein-delivery systems enter cells through endocytic pathways, but endosomal escape is a difficult and inefficient process, demanding fundamentally different methods of delivery. We report ultrasmall cationic molecularly imprinted nanoparticles that bind protein targets with high specificity through their uniquely distributed surface lysine groups.
View Article and Find Full Text PDFMovi: A fast and cache-efficient full-text pangenome index.
iScience
December 2024
Department of Computer Science, Johns Hopkins University, Baltimore, MD 21218, US.
Pangenome indexes are promising tools for many applications, including classification of nanopore sequencing reads. Move structure is a compressed-index data structure based on the Burrows-Wheeler Transform (BWT). It offers simultaneous O(1)-time queries and O(r) space, where r is the number of BWT runs (consecutive sequence of identical characters).
View Article and Find Full Text PDFAre slow-growing broiler chickens actually better for animal welfare? Shining light on a poultry welfare concern using a farm-scale economic model.
Br Poult Sci
January 2025
Animal Ask, UK.
1. It remains unclear whether slow-growing broilers actually represent an overall animal welfare improvement - a major knowledge gap for policymakers and animal welfare NGOs. This paper addresses this knowledge gap by using an economic model to produce an all-things-considered estimate of the welfare effects of slow-growing genotypes.
View Article and Find Full Text PDFScreening approaches and potential of isolated lactic acid bacteria for improving fermentation of Saccharina latissima.
BMC Biotechnol
January 2025
National Food Institute, Technical University of Denmark, Kgs. Lyngby, 2800, Denmark.
Background: With the growing interest in applying fermentation to seaweed biomasses, there is a need for fast and efficient selection of microbial strains that have the ability to 1) acidify quickly, 2) utilize seaweed constituents and c) exhibit some proteolytic activity. The present study aims to provide a fast methodology to screen large bacterial collections for potential applications in optimized seaweed fermentations, as well as investigate and assess the performance of a selected bacterial collection of the National Food Institute Culture Collection (NFICC) in seaweed fermentation. This approach is directed toward high-throughput (HT) methodologies, employing microwell assays for different phenotypical characteristics of lactic acid bacteria isolated from different sources.
View Article and Find Full Text PDFDrp1-Dependent Mitochondrial Fission Contributes to Lactic Acid-Induced Chicken Cardiomyocyte Damage.
J Biochem Mol Toxicol
January 2025
College of Animal Science and Technology, Henan Institute of Science and Technology, Xinxiang, China.
Enhanced glycolysis and elevated lactic acid (LA) production are observed during sudden death syndrome (SDS) in broilers. However, the mechanism underlying LA-induced cardiomyocyte damage and heart failure in fast-growing broilers remains unclear. In this study, chicken embryo cardiomyocytes (CECs) were cultured and treated with LA to investigate LA-induced CEC injury and its mechanism, aiming to develop strategies to prevent LA-induced SDS in broilers.
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