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Circulating Tumor DNA for Prediction of Complete Pathological Response to Neoadjuvant Radiochemotherapy in Locally Advanced Rectal Cancer (NEORECT Trial).
Cancers (Basel)
December 2024
Pathology, Faculty of Medicine, University of Augsburg, 86156 Augsburg, Germany.
Background/objectives: Locally advanced rectal cancer is treated with neoadjuvant chemoradiotherapy (nCRT) followed by total mesorectal excision (TME). As this approach achieves complete pathologic remissions (pCR) in approximately 30% of patients, it raises the question of whether surgery is always necessary. Non-surgical strategies, such as "watch and wait" (W&W), have shown similarly promising outcomes.
View Article and Find Full Text PDFMulti-level cognitive state classification of learners using complex brain networks and interpretable machine learning.
Cogn Neurodyn
December 2025
National Engineering Research Center of Educational Big Data, Central China Normal University, Luoyu Road, Wuhan, 430079 Hubei China.
Identifying the cognitive state can help educators understand the evolving thought processes of learners, and it is important in promoting the development of higher-order thinking skills (HOTS). Cognitive neuroscience research identifies cognitive states by designing experimental tasks and recording electroencephalography (EEG) signals during task performance. However, most of the previous studies primarily concentrated on extracting features from individual channels in single-type tasks, ignoring the interconnection across channels.
View Article and Find Full Text PDFEffects of Emotional States on Reproducibilities of Rest Position, Social and Spontaneous Smiles, and Speech.
Turk J Orthod
December 2024
Ege University Faculty of Dentistry, Department of Orthodontics, İzmir, Turkey.
Objective: To evaluate the effect of emotional states on reproducibilities of rest position, social and spontaneous smiles, and speech.
Methods: A total of 30 individuals aged 18-22 years were included (mean age; 19.03 years ±1.
Association between physical activity and sedentary behavior and gestational diabetes mellitus: a Mendelian randomization analysis.
Front Endocrinol (Lausanne)
December 2024
The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
Introduction: The evidence of association between physical activity (PA), sedentary behavior (SB) and gestational diabetes mellitus (GDM) remains controversial in observational studies, this study aimed to generate new hypotheses between PA, SB and GDM.
Methods: Our study performed Mendelian randomization (MR) analysis to explore the effects of three types of PA (moderate physical activity (MPA), moderate to vigorous physical activity (MVPA), accelerometer-based physical activity (ABPA)), three types of SB (television watching (TV), leisure computer use (PC), driving (DR)) on GDM and the mediating effect of body mass index (BMI). The inverse variance weighted method was used for the major analysis.
Effects of Foot Somatosensory Training on Plantar Somatosensory Function.
Cureus
December 2024
Department of Physical Therapy, Faculty of Nursing and Rehabilitation, Chubu Gakuin University, Seki, JPN.
Background Declines in foot somatosensory function can negatively impact balance and daily activities, particularly in older adults and individuals with neurological conditions. Despite this, effective physical therapeutic interventions to improve foot sensory function are limited. This study assessed the effects of targeted foot somatosensory training on plantar sensory function in healthy young adults.
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