To develop a nomogram for differential diagnosis between advanced and early pediatric appendicitis (PA). We retrospectively studied 669 PA patients. Patient characteristics and 24 serum markers were subjected to univariate and multivariate analysis, based on which the nomogram was constructed. Fibrin degradation product, CRP and Na differed significantly between the advanced and early PA. The value of area under the receiver operating characteristic curve (AUC) was 0.8602, which was greater than that of a single serum marker. Furthermore, the nomogram showed better discriminative ability than the biomarker alone. Notably, validation indicated high stability and reproducibility. The nomogram is superior to the serum marker alone, and may hold promise in clinical application.
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