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Induction of PD-1 and CD44 in CD4 T cells by circulatory extracellular vesicles from severe dengue patients drives endothelial damage via the NF-kB signaling pathway.
J Virol
December 2024
Laboratory of Virology, Regional Centre for Biotechnology, National Capital Region Biotechnology Science Cluster, Faridabad, Haryana, India.
Extracellular vesicles (EVs) emerged as critical contributors to the pathogenesis of vascular endothelial barrier dysfunction during the inflammatory response to infection. However, the contribution of circulating EVs to modifying endothelial function during dengue virus infection remains unclear. In this study, we showed that severe dengue patients' plasma-derived EV (SD-EV) were found to carry elevated levels of different protein cargos, e.
View Article and Find Full Text PDFHypoalbuminemia as a predictor of severe dengue: a systematic review and meta-analysis.
Expert Rev Anti Infect Ther
January 2025
Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
Introduction: Dengue fever is a significant health concern globally, especially in tropical regions. Identifying reliable markers for severe dengue, such as hypoalbuminemia, is crucial for early diagnosis and treatment.
Methods: This review systematically explores the association between hypoalbuminemia and severe dengue.
Trends in dengue virus positivity & serotyping in Rajasthan.
Indian J Med Res
November 2024
Department of Health Research, Indian Council of Medical Research, New Delhi, India.
Background & objectives Dengue virus causes frequent outbreaks and epidemics with high morbidity and mortality. It is important to monitor the trends of the dengue virus and its serotypes. We carried out the present work to study the prevalence of the dengue virus and its serotypes in clinically suspected cases of dengue in Rajasthan.
View Article and Find Full Text PDFCo-circulation of dengue serotypes in East Delhi: A new threat.
Med J Armed Forces India
December 2024
Director & Professor, Viral Research Diagnostic Laboratory, UCMS, GTB Hospital, Delhi, India.
Viral-host molecular interactions and metabolic modulation: Strategies to inhibit flaviviruses pathogenesis.
World J Virol
December 2024
Department of Obstetrics and Gynecology, Ewha Womans University, Seoul 07985, South Korea.
Flaviviruses, which include globally impactful pathogens, such as West Nile virus, yellow fever virus, Zika virus, Japanese encephalitis virus, and dengue virus, contribute significantly to human infections. Despite the ongoing emergence and resurgence of flavivirus-mediated pathogenesis, the absence of specific therapeutic options remains a challenge in the prevention and treatment of flaviviral infections. Through the intricate processes of fusion, transcription, replication, and maturation, the complex interplay of viral and host metabolic interactions affects pathophysiology.
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