AI Article Synopsis
- Enzymatically synthesized poly (glycerol adipate) (PGA) is a promising biomaterial for drug delivery, thanks to its favorable properties like biodegradability and biocompatibility.
- * This polymer is created through a simplified step-growth polymerization process catalyzed by lipase, which allows for easy functionalization and requires minimal purification and low-cost reagents.
- * The study reviews the literature on PGA's synthesis and modifications, as well as its applications in drug and gene delivery, highlighting recent developments in PGA-drug conjugation techniques.
Article Abstract
The enzymatically synthesized poly (glycerol adipate) (PGA) has demonstrated all the desirable key properties required from a performing biomaterial to be considered a versatile "polymeric-tool" in the broad field of drug delivery. The step-growth polymerization pathway catalyzed by lipase generates a highly functionalizable platform while avoiding tedious steps of protection and deprotection. Synthesis requires only minor purification steps and uses cheap and readily available reagents. The final polymeric material is biodegradable, biocompatible and intrinsically amphiphilic, with a good propensity to self-assemble into nanoparticles (NPs). The free hydroxyl group lends itself to a variety of chemical derivatizations via simple reaction pathways which alter its physico-chemical properties with a possibility to generate an endless number of possible active macromolecules. The present work aims to summarize the available literature about PGA synthesis, architecture alterations, chemical modifications and its application in drug and gene delivery as a versatile carrier. Following on from this, the evolution of the concept of enzymatically-degradable PGA-drug conjugation has been explored, reporting recent examples in the literature.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835762 | PMC |
| http://dx.doi.org/10.3390/polym11101561 | DOI Listing |
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