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The role of lin-12 notch in C. elegans anchor cell proliferation.
Biol Open
December 2024
Department of Dermatology, University of Zurich, University Hospital Zurich, Schlieren CH-8952, Switzerland.
The gonadal anchor cell (AC) is an essential organizer for the development of the egg-laying organ in the C. elegans hermaphrodite. Recent work has investigated the mechanisms that control the quiescent state the AC adopts while fulfilling its functions.
View Article and Find Full Text PDFThe creatine kinase (CK) is a key enzyme involved in brain bioenergetics, playing a key role in brain function and the pathogenesis of neurological and psychiatric diseases, but imaging its activity noninvasively in the human brain in vivo remains a significant challenge. This study aims to advance the magnetization transfer (MT)- P magnetic resonance fingerprinting (MRF) for 3D Creatine Kinase Imaging (CKI). The method was implemented and validated on a clinical 7 Tesla MRI scanner.
View Article and Find Full Text PDFDistinct functions of three Wnt proteins control mirror-symmetric organogenesis in the gonad.
Elife
November 2024
Multicellular Organization Laboratory, Department of Gene Function and Phenomics, National Institute of Genetics, Research Organization of Information and Systems (ROIS), Mishima, Japan.
Organogenesis requires the proper production of diverse cell types and their positioning/migration. However, the coordination of these processes during development remains poorly understood. The gonad in exhibits a mirror-symmetric structure guided by the migration of distal tip cells (DTCs), which result from asymmetric divisions of somatic gonadal precursors (SGPs; Z1 and Z4).
View Article and Find Full Text PDFS-RBD-modified and miR-486-5p-engineered exosomes derived from mesenchymal stem cells suppress ferroptosis and alleviate radiation-induced lung injury and long-term pulmonary fibrosis.
J Nanobiotechnology
October 2024
Department of Special Medicine, School of Basic Medicine, Qingdao University, Qingdao, 266071, People's Republic of China.
Article Synopsis
- Radiation-induced lung injury (RILI) causes cell death and fibrosis in lungs, but MSC-derived exosomes can help, although they lack targeting abilities and specific effects.
- A study engineered these exosomes with the SARS-CoV-2 spike protein and the miRNA miR-486-5p to enhance their therapeutic effects.
- The modified exosomes promoted lung cell growth and migration, reduced RILI and fibrosis, and inhibited ferroptosis by regulating fibrosis-related genes both in vitro and in vivo.
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