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| http://dx.doi.org/10.1016/S2213-2600(19)30272-3 | DOI Listing |
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Re-analysis of data from cluster randomised trials to explore the impact of model choice on estimates of odds ratios: study protocol.
Trials
December 2024
MRC Clinical Trials Unit at UCL, University College London, London, UK.
Background: There are numerous approaches available to analyse data from cluster randomised trials. These include cluster-level summary methods and individual-level methods accounting for clustering, such as generalised estimating equations and generalised linear mixed models. There has been much methodological work showing that estimates of treatment effects can vary depending on the choice of approach, particularly when estimating odds ratios, essentially because the different approaches target different estimands.
View Article and Find Full Text PDFMethodological insights from the EPISTOP trial to designing clinical trials in rare diseases-A secondary analysis of a randomized clinical trial.
PLoS One
December 2024
Department of Pediatric Neurology, Imagine Institute Paris, Necker-Enfants Maelades Hospital, Reference Centre for Rare Epilepsies, Member of Epicare, University Paris cite, Paris, France.
Background: In clinical research, the most appropriate way to assess the effect of an intervention is to conduct a randomized controlled trial (RCT). In the field of rare diseases, conducting an RCT is challenging, resulting in a low rate of clinical trials, with a high frequency of early termination and unpublished trials. The aim of the EPISTOP trial was to compare outcomes in infants with tuberous sclerosis (TSC) who received vigabatrin preventively before the seizures onset with those who received it conventionally after.
View Article and Find Full Text PDFA Bayesian reanalysis of the CULPRIT-SHOCK trial.
Eur Heart J Acute Cardiovasc Care
October 2024
Department of Cardiology, Heart Center Leipzig at University of Leipzig and Leipzig Heart Science, Leipzig, Germany.
Aims: The optimal revascularization strategy for patients with acute myocardial infarction (AMI), cardiogenic shock (CS), and multivessel disease remains controversial. The CULPRIT-SHOCK trial compared culprit lesion-only vs. immediate multivessel percutaneous coronary intervention (PCI), providing important data but leaving efficacy questions unresolved.
View Article and Find Full Text PDFExtracorporeal cardiopulmonary resuscitation versus conventional CPR in cardiac arrest: an updated meta-analysis and trial sequential analysis.
Crit Care
February 2024
Preventive Services, Graduate School of Medicine, School of Public Health, Kyoto University, Kyoto, Japan.
Background: Extracorporeal cardiopulmonary resuscitation (ECPR) may reduce mortality and improve neurological outcomes in patients with cardiac arrest. We updated our existing meta-analysis and trial sequential analysis to further evaluate ECPR compared to conventional CPR (CCPR).
Methods: We searched three international databases from 1 January 2000 through 1 November 2023, for randomised controlled trials or propensity score matched studies (PSMs) comparing ECPR to CCPR in both out-of-hospital cardiac arrest (OHCA) and in-hospital cardiac arrest (IHCA).
Could an integrated model of health and social care after critical illness reduce socioeconomic disparities in outcomes? A Bayesian analysis.
BJA Open
March 2024
University of Glasgow, School of Medicine, Dentistry and Nursing, Glasgow, UK.
Background: There is limited evidence to understand what impact, if any, recovery services might have for patients across the socioeconomic spectrum after critical illness. We analysed data from a multicentre critical care recovery programme to understand the impact of this programme across the socioeconomic spectrum.
Methods: The setting for this pre-planned secondary analysis was a critical care rehabilitation programme-Intensive Care Syndrome: Promoting Independence and Return to Employment.
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