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Erythropoietin-induced cluster of seizures in two children with cerebral palsy.
Acta Neurol Belg
August 2020
Department of Pediatrics, Istanbul University, Istanbul, Turkey.
A Potent Conformation-Constrained Synthetic Peptide Mimic of a Homeodomain Selectively Regulates Target Genes in Cells.
ACS Chem Biol
August 2018
Department of Biophysics , Bose Institute, P-1/12 CIT Scheme VIIM , Kolkata 700054 , India.
DNA, as a target for therapeutic intervention, remains largely unexplored. DLX-4, a homeodomain containing transcription factor, and its spliced isoforms play crucial roles in many aspects of cellular biochemistry and important roles in many diseases. A smaller peptide mimicking the homeodomain of the transcription factor DLX-4 was designed and synthesized by suitable conjoining of its modified DNA-binding elements.
View Article and Find Full Text PDFErythropoietin-induced changes in brain gene expression reveal induction of synaptic plasticity genes in experimental stroke.
Proc Natl Acad Sci U S A
June 2012
Brighton and Sussex Medical School, Falmer BN19RY, United Kingdom.
Erythropoietin (EPO) is a neuroprotective cytokine in models of ischemic and nervous system injury, where it reduces neuronal apoptosis and inflammatory cytokines and increases neurogenesis and angiogenesis. EPO also improves cognition in healthy volunteers and schizophrenic patients. We studied the effect of EPO administration on the gene-expression profile in the ischemic cortex of rats after cerebral ischemia at early time points (2 and 6 h).
View Article and Find Full Text PDFModulation of homeobox gene expression alters the phenotype of human hematopoietic cell lines.
EMBO J
March 1992
Veterans Affairs Medical Center, San Francisco, CA 94121.
We have previously reported that certain genes of the HOX2 cluster of homeobox genes on human chromosome 17 are specifically expressed in human leukemic cell lines with erythroid potential, suggesting that these genes are involved in hematopoietic differentiation. We now show that the expression of the HOX 2.2 gene decreases during erythropoietin-induced differentiation of the erythroid cell line MB02.
View Article and Find Full Text PDFUltrastructural studies of erythropoietin effects on the bone marrow of control and hypertransfused (65 hct) mice revealed a decrease in adventitial cell cover of the sinus apertures in erythropoietin-treated animals. A more striking finding, however, was the marked inhibition of erythropoietin-induced reticulocytosis by hypertransfusion itself. Hypertransfusion of the erythropoietin-treated animals appeared to decrease the reticulocyte response by inhibiting reticulocyte response by marrow cords in addition to inhibiting erythroid proliferation.
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