AI Article Synopsis
- The study identifies hsa-miR-4756-3p as a key microRNA in triple negative breast cancer (TNBC), influencing important cancer cell functions like apoptosis and migration.
- hsa-miR-4756-3p was shown to suppress TGF-β1 signaling and tumor growth in TNBC cell lines, indicating its potential as a therapeutic target.
- Forkhead box protein M1 (FOXM1) is a target of hsa-miR-4756-3p, and its knockout prevents hsa-miR-4756-3p-induced cancer cell migration and signaling, highlighting the FOXM1-TGFβ1-EMT pathway in cancer progression.
Article Abstract
Both aberrantly expressed mRNAs and micro(mi)RNAs play important roles in cancer cell function, which makes integration analysis difficult. In this study, we first applied master regulator analysisalgorithm and confirmed hsa-miR-4756-3p as a candidate miRNA in triple negative breast cancer (TNBC) patients; hsa-miR-4756-3p could regulate TNBC cell line apoptosis, proliferation, migration, and cell cycle as well as suppress TGF-β1 signalling andtumour growth. In TNBC, forkhead box protein M1 (FOXM1)was found to be an hsa-miR-4756-3p target gene, and FOXM1 knockout completely inhibited hsa-miR-4756-3p-induced cell migration and metastasis, TGF-β1 signalling, and epithelial mesenchymal signal activation, which indicated that hsa-miR-4756-3p functions via the FOXM1-TGFβ1-EMT axis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761188 | PMC |
| http://dx.doi.org/10.1038/s41598-019-50248-3 | DOI Listing |
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