Background: CSF1/CSF1R neuroinflammatory signaling is emerging as an important pathway involved in the pathogenesis of Parkinson's disease (PD). However, the genetic associations between / and PD have not yet been explored.
Methods: We investigated the effects of two functional genetic variants, including rs1058885 and rs10079250 in a cohort including 502 Taiwanese patients with PD and 511 age- and gender-matched healthy controls.
Results: The rs1058885 TT genotype was less frequent in PD patients compared with control subjects (odds ratio (OR) = 0.63, 95% confidence interval (CI): 0.43-0.92, = 0.015). The PD patients also had a lower frequency of the rs1058885 T allele compared with the control subjects (OR = 0.80, 95% CI: 0.67-0.96, = 0.014). No statistically significant differences in allelic and genotypic frequencies of rs10079250 between the PD and control subjects were found, even after stratification by age at onset and gender.
Conclusion: This study reports a genetic association between and PD for the first time.
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| http://dx.doi.org/10.3390/jcm8101529 | DOI Listing |
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