Objectives: Ischemic mitral regurgitation (IMR) is a common finding following myocardial infarction or ischemia. Management of moderate IMR is still a hot topic. Adding mitral valve repair (MVr) to coronary artery bypass grafting (CABG) is questionable. The goal of this study was to assess and compare short-term clinical and echocardiographic results of moderate IMR treated by CABG alone versus another group of patients treated by CABG plus MVr.
Methods: Eighty consecutive patients with ischemic heart disease (IHD) and moderate IMR were divided randomly into two equal groups: group I (40) had only CABG and group II (40) had CABG plus MVr. Patients were evaluated at 1-week, 3-months and 1-year intervals postoperatively.
Results: After 1-year follow-up, our study revealed statistically significant improvement in the grade of mitral regurgitation (MR) in group II than group I. The mean value for effective regurgitant orifice area (EROA) was 0.22 ± 0.13 for group I versus 0.03 ± 0.03 for group II (P = 0.001) and for vena contracta (VC), it was 3.8 ± 2.24 for group I versus 0.4 ± 0.49 for group II (P = 0.000). There was also a significant reduction in the New York Heart Association (NYHA) functional class in both groups.
Conclusions: MVr can be performed safely and concomitantly with CABG in patients having moderate IMR, and its addition to CABG have significant short-term impact on clinical or echocardiographic outcome of patients.
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http://dx.doi.org/10.1007/s11748-019-01212-5 | DOI Listing |
Malar J
January 2025
Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.
Background: In moderate-to-high malaria transmission regions, the World Health Organization recommends intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) alongside insecticide-treated bed nets to reduce the adverse consequences of pregnancy-associated malaria. Due to high-grade Plasmodium falciparum resistance to SP, novel treatment regimens need to be evaluated for IPTp, but these increase pill burden and treatment days. The present qualitative study assessed the acceptability of IPTp-SP plus dihydroartemisinin-piperaquine (DP) in Papua New Guinea, where IPTp-SP was implemented in 2009.
View Article and Find Full Text PDFBr J Psychol
January 2025
URMIS (UMR CNRS 8245-IMR IRD 205), University of Cote d'Azur, Pôle Universitaire Saint-Jean d'Angely, SJA3, MSHS, Nice Cedex 4, France.
Prior research has established that being a target of offline and online victimization might function as a significant risk factor that increases the likelihood of adolescents' involvement in cyberhate. Yet, relatively little is known about the mediating and moderating mechanisms underlying this relationship. To fill this important gap in knowledge, the present study aims to examine (1) whether excessive Internet use and contact with unknown people online act as sequential mediators in the relationship between overall victimization and youth's involvement in cyberhate; and (2) whether restrictive parental mediation has any role to play in moderating this relationship.
View Article and Find Full Text PDFEnviron Res
December 2024
International Institute for Applied Systems Analysis (IIASA), Wittgenstein Centre for Demography and Global Human Capital (IIASA, OeAW, University of Vienna), Schloßplatz 1, 2361, Laxenburg, Austria. Electronic address:
The present study investigates how ecosystem resilience affects children's health and acts as a protective shield against high temperature exposure. Ecosystem resilience is the ability of an ecosystem to absorb anthropogenic or climatic shocks and recover from those shocks. The study used various data sources to estimate the impact of temperature extremes on child mortality in India.
View Article and Find Full Text PDFArq Bras Cardiol
November 2024
Department of Research, U. N. Mehta Institute of Cardiology and Research Centre (UNMICRC), Civil Hospital Campus, Gujarat - Índia.
Background: The optimal treatment for ischemic mitral regurgitation (IMR) in patients of non-ST elevation myocardial infarction (NSTEMI) is a debated topic.
Objective: To evaluate the long term outcome on patients with NSTEMI and IMR, particularly emphasizing the comparison of treatments in those with moderate to severe MR.
Methods: We enrolled patients with NSTEMI and classified non/trivial to mild regurgitation as insignificant IMR and moderate to severe regurgitation as significant IMR.
Zhonghua Wai Ke Za Zhi
January 2025
Department of Cardiac Surgery, Linfen People's Hospital, Linfen041000, China.
To evaluate the clinical outcomes of combined complete preservation of chordal structure mitral valve replacement (C-MVR) with total anatomical arterial myocardial revascularization (TACR) in coronary patients with moderate-to-severe or severe ischemic mitral regurgitation (IMR). This is a retrospective multi-center case series study. Data were retrospectively collected from 127 patients with coronary artery disease with moderate to severe or severe IMR who received TACR with C-MVR from July 2015 to April 2024 in 13 hospitals in China.
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