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Cost-effectiveness of one-stop-shop [F]Fluorocholine PET/CT to localise parathyroid adenomas in patients suffering from primary hyperparathyroidism.
Eur J Nucl Med Mol Imaging
October 2024
Department of Radiology, Section Nuclear Medicine, Leiden University Medical Centre, Leiden, The Netherlands.
Purpose: We conducted a cost-effectiveness analysis in which we compared a preoperative [F]Fluorocholine PET/CT-based one-stop-shop imaging strategy with current best practice in which [F]Fluorocholine PET/CT is only recommended after negative or inconclusive [Tc]Tc-methoxy isobutyl isonitrile SPECT/CT for patients suffering from primary hyperparathyroidism. We investigated whether the one-stop-shop strategy performs as well as current best practice but at lower costs.
Methods: We developed a cohort-level state transition model to evaluate both imaging strategies respecting an intraoperative parathyroid hormone monitored treatment setting as well as a traditional treatment setting.
Comparison of F-sodium fluoride PET/CT, F-fluorocholine PET/CT and diffusion-weighted MRI for the detection of bone metastases in recurrent prostate cancer: a cost-effectiveness analysis in France.
BMC Med Imaging
March 2020
AP-HP Health Economics Research Unit, INSERM UMR 1153, Paris, France.
Background: The diagnostic performance of F-sodium fluoride positron emission tomography/computed tomography (PET/CT) (NaF), F-fluorocholine PET/CT (FCH) and diffusion-weighted whole-body magnetic resonance imaging (DW-MRI) in detecting bone metastases in prostate cancer (PCa) patients with first biochemical recurrence (BCR) has already been published, but their cost-effectiveness in this indication have never been compared.
Methods: We performed trial-based and model-based economic evaluations. In the trial, PCa patients with first BCR after previous definitive treatment were prospectively included.
Incremental value of F-fluorocholine PET/CT in comparison with Ga-DOTA PET/CT in adrenal adenoma localization in a MEN1 patient.
Rev Esp Med Nucl Imagen Mol (Engl Ed)
December 2020
Department of Nuclear Medicine, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, RP China; Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan, RP China. Electronic address:
Incidental Detection of Parathyroid Adenoma on Somatostatin Receptor PET/CT and Incremental Role of F-Fluorocholine PET/CT in MEN1 Syndrome.
Nucl Med Mol Imaging
June 2018
1Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, 110029 India.
Multiple endocrine neoplasia type 1 (MEN1) syndrome is characterized by combined occurrence of tumors of endocrine glands including the parathyroid, the pancreatic islet cells, and the anterior pituitary gland. Parathyroid involvement is the most common manifestation and usually the first clinical involvement in MEN1 syndrome, followed by gastroentero-pancreatic neuroendocrine tumors (NETs). Here we present a case where the patient initially presented with metastatic gastric NET and a single parathyroid adenoma was detected incidentally on Ga-DOTANOC PET/CT done as part of post Lu-DOTATATE therapy (PRRT) follow-up.
View Article and Find Full Text PDFIncremental Value of 18F-Fluorocholine PET/CT in the Localization of Double Parathyroid Adenomas.
Clin Nucl Med
March 2017
From the *Unité thyroïde, Institut Jean Godinot, Reims; †Service d'endocrinologie, diabétologie, nutrition, ‡Service de chirurgie digestive et endocrinienne, and §Laboratoire d'anatomie et cytologie pathologique, Hôpital Robert Debré, CHU de Reims; ∥Service de médecine nucléaire, Institut Jean Godinot, Reims; ¶Laboratoire de Biophysique, UFR de médecine, Université de Reims Champagne Ardenne; and **CRESTIC EA 3804, Université de Reims Champagne Ardenne.
A 73-year-old man displaying primary hyperparathyroidism with severe hypercalcemia (Ca: 4.1 mmol/l, PTH > 600 pmol/l) was referred for preoperative localization of a parathyroid adenoma. Tc-pertechnetate and Tc-sestaMIBI dual tracer scintigraphy displayed a mild focal uptake in the projection of the right thyroid lobe with negative ultrasonography.
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