AI Article Synopsis
- A 19-month-old Holstein heifer exhibited inactivity and difficulty breathing, along with symptoms like wheezing and swollen lymph nodes.
- Cytology tests indicated the presence of large atypical lymphocytes in the cervical mass and lymph nodes, while elevated levels of lactate dehydrogenase and thymidine kinase were also noted.
- Autopsy confirmed enlarged lymph nodes and white tumor-like masses in various organs, leading to a final diagnosis of thymic B-cell lymphoma associated with bovine leukemia virus (BLV) infection.
Article Abstract
A 19-mo-old Holstein heifer was inactive and dyspneic. Physical examination revealed wheezing, exophthalmos, a cervical mass, and lymphadenopathy. Cytology of the cervical mass and lymph nodes showed predominantly large atypical lymphocytes. Lactate dehydrogenase and thymidine kinase activities were elevated. Although nested PCR for bovine leukemia virus (BLV) using blood was positive, quantitative PCR showed a low number of provirus copies. Autopsy revealed enlargement of most lymph nodes examined, as well as white masses of various sizes in muscles of the left hindlimb and thoracic and abdominal organs. Histopathology revealed severe infiltration with neoplastic lymphocytes in these organs. The cervical mass was immune-positive for B-cell markers. The final diagnosis was thymic B-cell lymphoma with BLV infection.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900721 | PMC |
| http://dx.doi.org/10.1177/1040638719875501 | DOI Listing |
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