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| http://dx.doi.org/10.1159/000503633 | DOI Listing |
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Inflammatory Myopathies and Autoimmune Gluten-related Disorders: A Scoping Review of Pathophysiological Interconnections and Hypothesis.
Recent Adv Inflamm Allergy Drug Discov
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Department of Rheumatology, Dermatology and Infectious Diseases, Oslo University Hospital, Rikshospitalet, 0424 Oslo, Norway.
Introduction: Anecdotal reports describe patients with concurrent idiopathic inflammatory myopathy (IIM) and celiac disease (CeD) in whom the introduction of a gluten-free diet led to dramatic improvement of myositis. We first systematically reviewed all peer-reviewed publications on concomitant IIM and duodenal biopsy-verified CeD. The collected evidence was suggestive of associations between myositis disease activity and gluten exposure in some patients with IIM-CeD.
View Article and Find Full Text PDFGluten Unraveled: Latest Insights on Terminology, Diagnosis, Pathophysiology, Dietary Strategies, and Intestinal Microbiota Modulations-A Decade in Review.
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Department of Pharmaceutical Botany, Faculty of Pharmacy, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania.
A decade of research on gluten-related disorders (GRDs) is reviewed in this study, with a particular emphasis on celiac disease (CD) and non-celiac gluten sensitivity (NCGS). GRDs are triggered by the ingestion of gluten and gluten-like proteins found in wheat, barley, and rye. These proteins lead to intestinal damage in celiac disease, an autoimmune condition characterized by villous atrophy and a variety of gastrointestinal and extraintestinal symptoms.
View Article and Find Full Text PDFReflux, eosinophilic esophagitis, and celiac disease - the blurred lines.
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Department of Medicine, Division of Gastroenterology and Hepatology, Stanford University, Stanford, California, USA.
Article Synopsis
- Gastroesophageal reflux disease (GERD) is a common cause of dysphagia, while eosinophilic esophagitis (EoE) and celiac disease are rarer but often overlooked, making diagnosis challenging due to symptom overlap.
- Recent research has improved understanding of how dysphagia manifests in these conditions, emphasizing the importance of tests like upper endoscopy and biopsies, while also introducing new diagnostic methods.
- Properly distinguishing between GERD, EoE, and celiac disease is essential for effective treatment; EoE should be suspected in GERD patients who don't respond to standard therapy, and celiac disease should be considered if dysphagia occurs with
Cysteine cathepsins and autoimmune diseases: A bidirectional Mendelian randomization.
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Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Cysteine cathepsins are proteolytic enzymes crucial in various physiological and pathological processes, primarily operating within lysosomes. Their functions include protein degradation, immune system regulation, and involvement in various diseases. While some cysteine cathepsins play important roles in the immune system, their connection to autoimmune diseases remains unclear.
View Article and Find Full Text PDFMidterm single-center results with the use of custom-made endografts with inner branches: a call for attention.
J Vasc Surg
October 2024
Department of Vascular Medicine, German Aortic Center Hamburg, University Heart and Vascular Center UKE Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
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- The study aimed to assess the effectiveness and safety of bridging covered stents (BCS) connected to inner branches of custom-made thoracoabdominal endografts during endovascular aortic repair procedures.
- Conducted between 2019-2022, it involved 69 patients, reporting a high technical success rate of 99%, but also noted a 23% complication rate and 9% perioperative mortality.
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