We present a study of a graphene-based Josephson junction with dedicated side gates carved from the same sheet of graphene as the junction itself. These side gates are highly efficient and allow us to modulate carrier density along either edge of the junction in a wide range. In particular, in magnetic fields in the 1- to 2-T range, we are able to populate the next Landau level, resulting in Hall plateaus with conductance that differs from the bulk filling factor. When counter-propagating quantum Hall edge states are introduced along either edge, we observe a supercurrent localized along that edge of the junction. Here, we study these supercurrents as a function of magnetic field and carrier density.
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http://dx.doi.org/10.1126/sciadv.aaw8693 | DOI Listing |
Proteins
January 2025
Institute of Transformative bio-Molecules, Nagoya University, Nagoya, Japan.
In plants, sugar will eventually be exported transporters (SWEETs) facilitate the translocation of mono- and disaccharides across membranes and play a critical role in modulating responses to gibberellin (GA3), a key growth hormone. However, the dynamic mechanisms underlying sucrose and GA3 binding and transport remain elusive. Here, we employed microsecond-scale molecular dynamics (MD) simulations to investigate the influence of sucrose and GA3 binding on SWEET13 transporter motions.
View Article and Find Full Text PDFCureus
December 2024
Pediatric Neurology, Bahrain Defence Force Hospital, Riffa, BHR.
Super-refractory status epilepticus (SRSE) is defined as status epilepticus that persists or recurs after treatment with anesthetic agents for more than 24 hours, including cases with recurrent seizures on reduction or withdrawal of anesthetic drugs. Super-refractory status epilepticus presents a significant challenge for neurologists, particularly when standard treatments fail to achieve seizure control. Lacosamide, which has a unique mechanism involving modulating voltage-gated sodium channels by enhancing their slow inactivation, has emerged as a potential option for managing SRSE.
View Article and Find Full Text PDFSmall
January 2025
eNDR Laboratory, School of Physics, IISER Thiruvananthapuram, Trivandrum, Kerala, 695551, India.
Iontronic memtransistors have emerged as technologically superior to conventional memristors for neuromorphic applications due to their low operating voltage, additional gate control, and enhanced energy efficiency. In this study, a side-gated iontronic organic memtransistor (SG-IOMT) device is explored as a potential energy-efficient hardware building block for fast neuromorphic computing. Its operational flexibility, which encompasses the complex integration of redox activities, ion dynamics, and polaron generation, makes this device intriguing for simultaneous information storage and processing, as it effectively overcomes the von Neumann bottleneck of conventional computing.
View Article and Find Full Text PDFBiophys J
January 2025
Michael Sars Centre, University of Bergen, Norway. Electronic address:
Neuropeptides are inter-cellular signaling molecules occurring throughout animals. Most neuropeptides bind and activate G-protein coupled receptors, but some also activate ionotropic receptors (or "ligand-gated ion channels"). This is exemplified by the tetra-peptide H-Phe-Met-Arg-Phe-NH (FMRFa), which activates mollusc and annelid FMRFa-gated sodium channels (FaNaCs) from the trimeric degenerin/epithelial sodium channel superfamily.
View Article and Find Full Text PDFJ Prev Alzheimers Dis
January 2025
Alzheimer's Therapeutic Research Institute, University of Southern California, San Diego, CA, United States.
Background: Investigators conducting clinical trials have an ethical, scientific, and regulatory obligation to protect the safety of trial participants. Traditionally, safety monitoring includes manual review and coding of adverse event data by expert clinicians.
Objectives: Our study explores the use of natural language processing (NLP) and artificial intelligence (AI) methods to streamline and standardize clinician coding of adverse event data in Alzheimer's disease (AD) clinical trials.
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