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The Safety and Late Hemodynamics of Donor Cardiac Undersizing in Heart Transplantation.
Ann Thorac Surg
December 2024
Department of Cardiac Surgery, Vanderbilt University Medical Center, Nashville Tennessee.
Background: Predicted heart mass ratio (PHMr) has become the standard donor-recipient size matching method in heart transplantation. While utilization of small PHMr hearts is associated with increased one-year mortality, the underlying mechanisms and time horizon of mortality remain uncertain.
Methods: A single institution analysis of isolated heart transplant recipients (01/2019-7/2022) was performed (N=334).
The Association of Echocardiographically Measured Donor Left Ventricular Mass and 1-Year Outcomes After Heart Transplantation.
JACC Heart Fail
November 2024
Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA. Electronic address:
Background: Donor-recipient heart size matching is crucial in heart transplantation; however, the often-used predicted heart mass (PHM) ratio may be inaccurate in the setting of obesity.
Objectives: In this study, the authors sought to investigate the association between echocardiographically measured donor left ventricular mass (LVM) for heart size matching and the risk of the primary 1-year composite outcome of death or retransplantation.
Methods: The Donor Heart Study was a prospective, multicenter, observational cohort study that collected echocardiograms from brain-dead donors.
Genomic epidemiology reveals the variation and transmission properties of SARS-CoV-2 in a single-source community outbreak.
Virus Evol
October 2024
Microbiology Laboratory, Nanjing Medical University Affiliated Nanjing Municipal Center for Disease Control and Prevention, 2 Zizhulin Road, Nanjing, Jiangsu 210003, China.
Article Synopsis
- - SARS-CoV-2, the virus causing COVID-19, led to a significant outbreak in Nanjing in March 2022, affecting 95 individuals and linked back to a single source case.
- - Researchers analyzed 61 viral samples and found they belonged to the BA.2.2 lineage, with genetic variations primarily identified as single-nucleotide variants (iSNVs), indicating significant genetic diversity within the outbreak.
- - The study highlights how iSNVs can transmit between individuals and become established in the viral population, helping to understand the dynamics of viral transmission and the emergence of diversity within a community.
Right Ventricular Mass Oversizing Is Associated With Improved Post-transplant Survival in Heart Transplant Recipients With Elevated Transpulmonary Gradient.
J Card Fail
October 2024
Department of Cardiothoracic Surgery, Pittsburgh, PA. Electronic address:
Background: This study evaluates the effects of pre-transplant transpulmonary gradient (TPG) and donor right ventricular mass (RVM) on outcomes following heart transplantation.
Methods: UNOS registry was queried to analyze adult recipients who underwent primary isolated heart transplantation from 1/1/2010 to 12/31/2018. The recipients were dichotomized into 2 groups based on their TPG at the time of transplantation, < 12 and ≥ 12 mmHg.
The small-for-size syndrome in living donor liver transplantation: current management.
Updates Surg
October 2024
Department of Liver Transplantation, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.
Small-for-size syndrome poses a significant challenge in living donor liver transplantation, with potentially severe consequences including liver failure and death. This review explores the management strategies for SFSS, starting from the pathophysiology of the disease. SFSS arises from insufficient liver mass in the graft and hyperdynamic circulation in cirrhotic recipients, leading to portal hyperperfusion and subsequent liver injury.
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