yeasts are generally found in the vaginal microbiota; however, disruption of the balance maintained by host factors and microorganisms results in vulvovaginal candidiasis (VVC). This study evaluated the antagonistic activity of vaginal spp. on to verify whether active compounds of spp. had antifungal and antivirulence activity. The antagonism assay showed that 15 out of 20 strains had an inhibitory effect on Biosurfactants displayed surface-tension-reducing activity, with the best value obtained for 1. ATCC 9595, ATCC 4356, and 11 produced biosurfactants that decreased adhesion and disrupted biofilm formation. The best results were obtained in the pre-incubation assay for 1 and 11. Overall, strains showed significant anti- activity, and their biosurfactants exhibited considerable anti-adhesion and antibiofilm activity against . To be considered safe for use in vivo, the safety of biosurfactant (BS) should be investigated using cytotoxicity assays.
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| http://dx.doi.org/10.3390/pathogens8030150 | DOI Listing |
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