AI Article Synopsis
- The study investigates the neutrophil-to-lymphocyte ratio (NLR) as a potential marker for disease activity in patients with relapsing-remitting multiple sclerosis (RRMS).
- A total of 84 out of 132 RRMS patients were analyzed, revealing a significant correlation between higher NLR values and increased disease activity at onset.
- The findings suggest that an elevated NLR may indicate active disease in early diagnosed RRMS patients, but further research with larger sample sizes is necessary for confirmation.
Article Abstract
Background: The role of the neutrophil-to-lymphocyte ratio (NLR) of peripheral blood has been investigated in relation to several autoimmune diseases. Limited studies have addressed the significance of the NLR in terms of being a marker of disease activity in multiple sclerosis (MS).
Methods: This is a retrospective study in relapsing-remitting MS patients (RRMS) admitted to the tertiary MS center of Catania, Italy during the period of 1 January to 31 December 2018. The aim of the present study was to investigate the significance of the NLR in reflecting the disease activity in a cohort of early diagnosed RRMS patients.
Results: Among a total sample of 132 patients diagnosed with RRMS, 84 were enrolled in the present study. In the association analysis, a relation between the NLR value and disease activity at onset was found (V-Cramer 0.271, = 0.013). In the logistic regression model, the variable NLR ( = 0.03 ExpB 3.5, CI 95% 1.089-11.4) was related to disease activity at onset.
Conclusion: An elevated NLR is associated with disease activity at onset in RRMS patients. More large-scale studies with a longer follow-up are needed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830321 | PMC |
| http://dx.doi.org/10.3390/cells8101114 | DOI Listing |
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