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NK Cell Plasticity in Cancer. | LitMetric

NK Cell Plasticity in Cancer.

J Clin Med

Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

Published: September 2019

Natural killer (NK) cells are critical immune components in controlling tumor growth and dissemination. Given their innate capacity to eliminate tumor cells without prior sensitization, NK-based therapies for cancer are actively pursued pre-clinically and clinically. However, recent data suggest that tumors could induce functional alterations in NK cells, polarizing them to tumor-promoting phenotypes. The potential functional plasticity of NK cells in the context of tumors could lead to undesirable outcomes of NK-cell based therapies. In this review, we will summarize to-date evidence of tumor-associated NK cell plasticity and provide our insights for future investigations and therapy development.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780970PMC
http://dx.doi.org/10.3390/jcm8091492DOI Listing

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