Carbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial therapies. Recent results from our laboratories from two structurally related scaffolds have shown promising activity against both and several parasitic strains. As a result, a small structure activity relationship study was designed to further probe their activity and potential. Their synthesis and the results of the subsequent biological activity are reported herein.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804079 | PMC |
| http://dx.doi.org/10.3390/molecules24193433 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Investigation of 5'-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents.
Molecules
September 2019
Department of Chemistry & Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA.
Carbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial therapies. Recent results from our laboratories from two structurally related scaffolds have shown promising activity against both and several parasitic strains. As a result, a small structure activity relationship study was designed to further probe their activity and potential.
View Article and Find Full Text PDF4'- and 1'-methyl-substituted 5'-norcarbanucleosides.
J Org Chem
November 2003
Department of Chemistry, Auburn University, Auburn, Alabama 36849-5312, USA.
5'-norcarbocyclic nucleosides have been found to possess a variety of meaningful biological properties. Derivatives of these compounds possessing substituents at the hydroxyl and heterocyclic ring bearing carbon atoms have not been described. As entries into these compounds, the 4'- and 1'-methyl derivatives of 5'-noraristeromycin (2 and 3) have been prepared from a common cyclopentyl precursor 8.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!