AI Article Synopsis
- The study examined how matching donor and recipient sex affects survival rates in simultaneous pancreas-kidney transplants.
- It found that more than half of the transplants were sex-matched but showed no significant differences in overall patient and graft survival between matched and mismatched groups.
- However, sex matching was associated with fewer severe postoperative complications, suggesting it may have some benefits in terms of surgical outcomes.
Article Abstract
Background: Several studies in solid organ transplantation have shown a correlation between donor and recipient sex mismatch and risk of graft loss. In this study, we aimed to analyze the impact of donor and recipient sex matching on patient and pancreas graft survival in a large single-center cohort.
Methods: We retrospectively analyzed all first simultaneous pancreas-kidney transplants performed between 1979 and 2017 at the Medical University of Innsbruck.
Results: Of 452 patients, 54.6% (247) received a sex-matched transplant. Patient survival (P = .86), death-censored pancreas graft survival (dcPGS, P = .26), and death-censored kidney graft survival (dcKGS, P = .24) were similar between the sex-matched and sex-mismatched groups. Patient survival and dcPGS at 1, 5, and 15 years were 95.9%, 90.0%, and 62.1% and 86.1%, 77.1%, and 56.7% in the sex-matched group and 93.6%, 86.2%, and 62.4% and 83.1%, 73.3%, and 54.3% in the sex-mismatched group. Sex matching led to a lower odds of severe postoperative complications (41.2% vs 49.0%; OR 0.57, 95%CI 0.33-0.97; P = .038); however, no increased odds of other adverse postoperative outcomes was detected.
Conclusion: Our study demonstrates that sex matching reduced the odds of postoperative complications but did not impact other early and late outcome parameters in our cohort.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899671 | PMC |
| http://dx.doi.org/10.1111/ctr.13717 | DOI Listing |
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