Objective: The present study aimed to investigate the effects of (JR) extract on hyperglycaemia and insulin sensitivity.
Methods: Forty rats were divided into 4 groups: Control (C), Diabetes Control (DC), Diabetes + (D + JR) and Diabetes + Metformin (D + M).
Results: In the D + JR group, Fasting blood glucose (FBG) levels decreased from day 14 onwards. There was a significant decrease in plasma levels of Fibronectin Type III Domain Containing 5 (FNDC5) and adiponectin (ADP) in the DC group compared to the C group ( < .01, < .001 respectively). In the D + JR group, there was a significant increase in plasma FNDC5 and ADP ( < .05), while the plasma Tumour necrosis factor-alpha (TNF-α) levels were decreased compared to the DC group ( < .001).
Conclusions: In conclusion, the present study found that JR and its bioactive components alleviated insulin resistance by increasing ADP and FNDC5 and decreasing FBG in a rat model of streptozotocin (STZ) + nicotinamide (NAD)-induced type 2 diabetes (T2D).Highlights extract increased insulin sensitivity. extract significantly reduced the level of fasting blood glucose. extract reduced TNF-α levels in rats with type 2 diabetes. extract prevent weight loss in type 2 diabetes.
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| http://dx.doi.org/10.1080/13813455.2019.1668018 | DOI Listing |
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