A 24-year-old male patient, in study for a hepatic tumor, was admitted to emergency due to hypovolemic shock and anemia. The abdominal CT scan showed an extensive expansive lesion of 11.8x11.7cm in liver segments II and III with rupture signs and lamellar hyperdense component of haematic and necrotic aspect, associated with free fluid in the abdominal cavity (Fig 1.A). The tumor markers (DHL, AFP, CEA) and viral serology were negative. The patient was submitted to surgery, an exploratory laparotomy + Pringle maneuver + II and III hepatic segmentectomy was performed. Abundant intra-abdominal blood was evidenced, and an extensive multilobed 20x20cm tumor dependent on II and III hepatic segments, a R2 surgery was achieved. The histological study showed a non-classifiable high grade sarcoma, CD56 positive (Fig. 1.B). The patient was discharged after 7 days.
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http://dx.doi.org/10.17235/reed.2019.6163/2019 | DOI Listing |
Nat Prod Res
March 2025
Department Biochemistry, Ebonyi State University, Abakaliki.
Exposure to heavy metals significantly contributes to insulin resistance, a major factor in type 2 diabetes. This study investigated the antioxidant and therapeutic potential of ethanol leaf extract of in mitigating heavy metal-induced insulin resistance, oxidative stress and inflammation in albino rats. Thirty rats were divided into five groups: Groups I and II received normal saline and a lead-mercury mixture, respectively, while Groups III, IV and V were treated with the extract (200, 400 and 600 mg/kg) for four weeks after exposure.
View Article and Find Full Text PDFNature
March 2025
Department of Medicine, Columbia University, New York, NY, USA.
Hepatic stellate cells (HSCs) have a central pathogenetic role in the development of liver fibrosis. However, their fibrosis-independent and homeostatic functions remain poorly understood. Here we demonstrate that genetic depletion of HSCs changes WNT activity and zonation of hepatocytes, leading to marked alterations in liver regeneration, cytochrome P450 metabolism and injury.
View Article and Find Full Text PDFAtherosclerosis
January 2025
Division of Endocrinology and Metabolism, Department of Medicine, M0682, University of California San Diego, 9500 Gilman Dr, La Jolla, CA, USA. Electronic address:
Familial chylomicronemia syndrome (FCS) is a rare, recessive monogenic disorder characterized by severely elevated plasma triglyceride (TG) levels due to absent or markedly impaired lipoprotein lipase activity, leading to a greatly increased risk of acute pancreatitis. Naturally occurring very low levels of apoC-III are associated with low TG levels; thus, apoC-III is a target for TG lowering, and therapies have been developed to reduce apoC-III. Strategies to inhibit hepatic apoC-III synthesis include antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs).
View Article and Find Full Text PDFExpert Rev Anti Infect Ther
March 2025
Head of the Infectious Diseases/Microbiology Department, Clínica Universidad de Navarra, Spain.
Introduction: This review considers special populations as those patients for whom Gram-positive infections are particularly challenging to treat. We examine the potential benefits of dalbavancin in these patients.
Areas Covered: We focus on patients with renal impairment, hepatic failure or obesity, and, also, pediatric patients, elderly patients and socially vulnerable individuals.
Arch Toxicol
March 2025
Experimental Hepatology Unit, Health Research Institute La Fe (IISLAFE), Torre A. Instituto Investigación Sanitaria La Fe Av Fernando Abril Martorell 106, 46026, Valencia, Spain.
Drug-induced cholestasis is one of the major mechanisms implicated in drug-induced hepatotoxicity that poses a serious problem in terms of patient morbidity and mortality, healthcare system expenses and efficacy of newly developed drugs. Impaired bile acid homeostasis due to transporter alterations, hepatocellular injury or canalicular abnormalities is the most characteristic feature of cholestasis. Given the complexity of cholestasis and the different underlying mechanisms, new models and technologies that span a variety of biological processes are needed to accurately predict drugs' cholestatic potential.
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