Myopia genetics in genome-wide association and post-genome-wide association study era.

Int J Ophthalmol

Department of Ophthalmology, Affiliated Hospital of North Sichuan Medical College; Department of Ophthalmology and Optometry, North Sichuan Medical College, Nanchong 637000, Sichuan Province, China.

Published: September 2019

Genome-wide association studies (GWAS) of myopia and refractive error have generated exciting results and identified novel risk-associated loci. However, the interpretation of the findings of GWAS of complex diseases is not straightforward and has remained challenging. This review provides a brief summary of the main focus on the advantages and limitations of GWAS of myopia, with potential strategies that may contribute to further insight into the genetics of myopia in the post-GWAS or omics era.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739571PMC
http://dx.doi.org/10.18240/ijo.2019.09.18DOI Listing

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