AI Article Synopsis
- The study investigates the role of delayed perihematomal edema (DHE) as a potential predictor of poor outcomes in patients with spontaneous intracerebral hemorrhage (sICH).
- Researchers analyzed data from 121 sICH patients to identify risk factors for DHE and its association with prognosis.
- Findings show that DHE is linked to factors like age and initial hematoma volume, with DHE itself increasing the risk of poor outcomes for sICH patients.
Article Abstract
Purpose: We hypothesize delayed perihematomal edema (DHE) leads to secondary injury after spontaneous intracerebral hemorrhage (sICH) with a poor prognosis. Hence, we need to investigate the risk factors of DHE and identify whether DHE will predict the poor outcome of sICH.
Methods: We retrospectively recruited 121 patients with sICH admitted to the Department of Neurology from January 2014 to August 2018. After dividing all these patients into DHE group and non-DHE group, we analyzed the potential risk factors and outcome of DHE using a multivariate logistic regression model.
Results: We conclude DHE after sICH associates with age, hospitalization time, hematoma shape, blood pressure upon admission, alcohol consumption, blood sodium level, and baseline hematoma volume within 24 hours after symptom onset, among which differences were statistically significant (P < .05). Logistic regression analysis finally identified that age (OR = 0.958, 95% CI = 0.923-0.995) and the baseline hematoma volume (OR = 1.161, 95% CI = 1.089-1.238) were the most significant risk factors for DHE, and moreover, the DHE (OR = 3.062, 95% CI = 1.196-7.839) was also a risk factor for poor prognosis in sICH patients.
Conclusion: We suggest DHE is a clinical predictor of secondary injury following sICH and poor prognosis. In addition, age and baseline hematoma volume are considered significant high-risk factors for DHE in patients with sICH.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776736 | PMC |
| http://dx.doi.org/10.1111/cns.13219 | DOI Listing |
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