AI Article Synopsis
- Gallbladder cancer (GBC) has a poor prognosis due to aggressive tumor behavior, late diagnosis, and limited treatment options.
- Early detection and assessment of disease severity are crucial for improving survival rates and guiding treatment, including participation in clinical trials.
- Advances in molecular research and next-generation sequencing have led to the identification of new diagnostic and prognostic biomarkers, which could enhance early diagnosis and targeted therapy for GBC patients.
Article Abstract
The most common malignancy of the biliary tract, gallbladder cancer (GBC) often has a dismal prognosis. The aggressive nature of the tumor, delayed diagnosis at advanced stages of the disease, and lack of effective treatment options are some of the factors that contribute to a poor outcome. Early detection and accurate assessment of disease burden is critical to optimize management and improve long-term survival, as well as identify patients for adjuvant therapy and clinical trials. With recent advances in the understanding of the molecular pathogenesis of GBC, several specific diagnostic and biomarkers have been proposed as being of diagnostic and prognostic importance. Indeed, identification of novel diagnostic and prognostic markers has an important role in early diagnosis and development of targeted therapies among patients with GBC. Next-generation sequencing technology and genomewide data analysis have provided novel insight into understanding the molecular pathogenesis of biliary tract cancers, thereby identifying potential biomarkers for clinical use. We herein review available GBC biomarkers and the potential clinical implications in the management of GBC.
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| http://dx.doi.org/10.1016/j.suronc.2019.09.006 | DOI Listing |
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