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| http://dx.doi.org/10.1038/s41433-019-0594-9 | DOI Listing |
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Divergent brain solute clearance in rat models of cerebral amyloid angiopathy and Alzheimer's disease.
iScience
December 2024
Department of Anesthesiology, Yale School of Medicine, New Haven, CT 06510, USA.
Brain waste clearance from the interstitial fluid environment is challenging to measure, which has contributed to controversy regarding the significance of glymphatic transport impairment for neurodegenerative processes. Dynamic contrast enhanced MRI (DCE-MRI) with cerebrospinal fluid administration of Gd-tagged tracers is often used to assess glymphatic system function. We previously quantified glymphatic transport from DCE-MRI data utilizing regularized optimal mass transport (rOMT) analysis, however, information specific to glymphatic clearance was not directly derived.
View Article and Find Full Text PDFBOLD-CSF dynamics assessed using real-time phase contrast CSF flow interleaved with cortical BOLD MRI.
Fluids Barriers CNS
December 2024
C.J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Background: Cerebrospinal fluid (CSF) motion and pulsatility has been proposed to play a crucial role in clearing brain waste. Although its driving forces remain debated, increasing evidence suggests that large amplitude vasomotion drives such CSF fluctuations. Recently, a fast blood-oxygen-level-dependent (BOLD) fMRI sequence was used to measure the coupling between CSF fluctuations and low-frequency hemodynamic oscillations in the human cortex.
View Article and Find Full Text PDFNeuroinflammatory Response in the Traumatic Brain Injury: An Update.
Neurochem Res
December 2024
Laboratory of Experimental Neurology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil.
The central nervous system (CNS) comprises membranes and barriers that are vital to brain homeostasis. Membranes form a robust shield around neural structures, ensuring protection and structural integrity. At the same time, barriers selectively regulate the exchange of substances between blood and brain tissue, which is essential for maintaining homeostasis.
View Article and Find Full Text PDFClinical Utility of DTI-ALPS in Identifying Dysfunction in the "Glymphatic" System.
J Magn Reson Imaging
December 2024
Neuroradiology Unit, Scientific Institute IRCCS Eugenio Medea, Bosisio Parini, Italy.
Clinical and radiologic distinctions between familial cavernous malformation syndrome and cerebral amyloid angiopathy.
Acta Neurochir (Wien)
December 2024
Department of Neurosurgery, Mayo Clinic, Rochester, MN, USA.
Purpose: Familial cerebral cavernous malformation syndrome (FCCM) is characterized by multiple hemorrhagic lesions and is sometimes mistaken for cerebral amyloid angiopathy (CAA).
Methods: We compared clinical and radiologic characteristics in patients with definite (N = 32) and presumed FCCM (n = 76) to patients with definite (N = 29) and probable CAA (N = 21).
Results: Patients with CAA were older (78.
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