PENELOPE simulations of a Vinten ionization chamber (IC) were performed to investigate the influence of the thickness of glass-ampoules used in Rn standardization. The simulation reveals a non-negligible variation of the energy deposited in the chamber gas region (which may induce a proportional variation of the measured current) when considering the β transition emissions of the daughters of Rn. This reinforces the idea of using a specialist container (made of metal to preserve the integrity of the container) that would circulate between the metrology laboratories in the context of international comparison exercises using the BIPM international reference system (SIR).
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http://dx.doi.org/10.1016/j.apradiso.2019.108886 | DOI Listing |
Phys Med Biol
January 2025
Radiotherapy and Radiation Dosimetry group, National Physical Laboratory, Hampton Road, Middlesex, Teddington, TW11 0LW, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.
Internationally, reference dosimetry for clinical proton beams largely follows the guidelines published by the International Atomic Energy Agency (IAEA TRS-398 Rev. 1, 2024). This approach yields a relative standard uncertainty of 1.
View Article and Find Full Text PDFAppl Radiat Isot
January 2025
National Institute of Metrology (NIM), Beijing, 100029, China.
A current measurement system named ICMS-TIA (Ionization Current Measurement System based on Transimpedance Amplifier) for rapid and accurate measurement of the ionization current of 4πγ ionization chamber is developed based on an improved high-value resistance I-V conversion method with range switching function. The effective measurement range of the ICMS-TIA is from 50 fA to 50 μA and the response time of the system is less than 2.8 s.
View Article and Find Full Text PDFInt J Part Ther
March 2025
Institute of Medical Physics and Radiation Protection, University of Applied Sciences, Giessen, Germany.
Purpose: The spot size of scanned particle beams is of crucial importance for the correct dose delivery and, therefore, plays a significant role in the quality assurance (QA) of pencil beam scanning ion beam therapy.
Materials And Methods: This study compares 5 detector types-radiochromic film, ionization chamber (IC) array, flat panel detector, multiwire chamber, and IC-for measuring the spot size of proton and carbon ion beams.
Results: Variations of up to 30% were found between detectors, underscoring the impact of detector choice on QA outcomes.
Tech Innov Patient Support Radiat Oncol
March 2025
Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Tokushima 770-8503, Japan.
Purpose: This study aims to compare treatment plans created using RapidPlan and PlanIQ for twelve patients with prostate cancer, focusing on dose uniformity, dose reduction to organs at risk (OARs), plan complexity, and dose verification accuracy. The goal is to identify the tool that demonstrates superior performance in achieving uniform target dose distribution and reducing OAR dose, while ensuring accurate dose verification.
Methods: Dose uniformity in the planning target volume, excluding the rectum, and dose reduction in the OARs (the rectum and bladder) were assessed.
J Neurosci Methods
January 2025
Cognitive Neuroscience Laboratory, German Primate Center - Leibniz Institute for Primate Research, Goettingen, Germany; Faculty of Biology and Psychology, University of Goettingen, Goettingen 37077 Germany.
Background: Neuronal activity is modulated by behavior and cognitive processes. The combination of several neurotransmitter systems, acting directly or indirectly on specific populations of neurons, underlie such modulations. Most studies with non-human primates (NHPs) fail to capture this complexity, partly due to the lack of adequate methods for reliably and simultaneously measuring a broad spectrum of neurotransmitters while the animal engages in behavioral tasks.
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