AI Article Synopsis
- * The reaction is compatible with various functional groups, making it a safer alternative compared to current methods that often use toxic reagents.
- * The researchers also demonstrate how this method can produce fluorine-labeled difluoroalkyl ethers, which have potential applications in medicine, materials science, and radiotracer creation.
Article Abstract
Herein we report the mild and rapid fluorodesulfurization of thionoesters using only silver(I) fluoride. This reaction demonstrates excellent functional group tolerance and complements existing strategies for difluoroalkyl ether synthesis, which rely on toxic and often dangerous reagents that demonstrate limited functional group compatibility. We additionally report the translation of this finding to the production of F-labelled difluoroalkyl ethers using fluoride-derived [ F]AgF. This new process should enable the synthesis of a wide range of difluoroalkyl ethers with applications in medicinal and materials chemistry, and radiotracer production.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/chem.201904132 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!