AI Article Synopsis
- Recent studies indicate that the FTO gene influences body weight by affecting the expression of the IRX3 gene, which is linked to obesity.
- The review analyzed various articles from 2000 to 2019, focusing on factors like polymorphism, BMI, and the IRX3 gene across multiple scientific databases.
- Findings suggest mixed results regarding IRX3's role in obesity, with some research showing that increased expression correlates with higher body weight while others indicate the opposite; more research is needed to clarify these relationships.
Article Abstract
Introduction: Recent studies reported that FTO exert its effects on body weight through change the expression IRX3. The aim of this study was investigation of the possible mechanisms of the effects of IRX3 gene on obesity.
Material And Methods: The present review was carried out using keywords such as polymorphism and/or obesity and/or BMI and/or IRX3 gene and/or Iroquois homeobox protein 3. Databases including PubMed, Science Direct, web of sciences, Scopus, and Cochran databases were used to collect all related articles published from 2000 to 2019.
Results: Based on this review, there are some evidences on the association between the IRX3 polymorphisms and the IRX3 expression level with body weight. In some studies, the up-regulation of IRX3 expression was related to increased body weight, while in some other studies down-regulation of IRX3 expression was related to obesity.
Conclusions: This review investigated the probable mechanisms of the effects of the IRX3 gene on obesity. Studies in this are limited and reported contradictory results. Further studies are required to evaluate the role of IRX3 gene in the associations between genes, diet, and obesity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749179 | PMC |
| http://dx.doi.org/10.5114/amsad.2019.87545 | DOI Listing |
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