Severity: Warning
Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 176
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3122
Function: getPubMedXML
File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
Our study is considered to attempt reducing the immune-toxic and antioxidant impacts of exposure to fipronil (FP) on Nile tilapia, Oreochromis niloticus using the β-glucan (βG). Two hundred and seventy fingerlings of Nile tilapia were divided randomly into six groups (45 tilapias of each, in 3 replicates): group I control (CT) group nourished on a basal diet. Group II (βG) nourished a basal diet supplemented with 0.4% βG. Groups III (1/20 FP) and V (1/10 FP) was exposed to 1/20 and 1/10 of the 96 h LC of FP in water and nourished the basal diet respectively. Groups IV (1/20 FP+ βG) and VI (1/10 FP+ βG) were exposed to 1/20 and 1/10 FP concomitantly with 0.4% βG supplementation for 90 successive days. Growth performance metrics were higher in βG group than CT. While those metrics were fallen at exposure to 1/20 or 1/10 FP. Supplementation with βG elevated the IgM and lysozyme levels.Whereas, tilapias exposed to FP only at different concentration showed lowering of those compared to CT. Supplementation with βG was effectively augmented IgM and lysozyme in 1/20 FP exposed tilapias. Furthermore, in a minor grade at 1/10 FP exposed tilapias. Exposure to FP increased the activities of hepatic markers chiefly at 1/10, however the βG supplementation was successfully improved these markers. There was imbalance of cortisol level at FP exposure where, βG combining to FP alleviate this disparity. There was fallen in LDH, MDH and FDPase in βG tilapias where continuing raise in 1/10 FP followed by 1/20 FP. βG supplementation raise the level of GSH, without significant variations in MDA conversely occurs in FP alone. Genes expression of βG caused raise of both GPx and GR, without fluctuations in CAT and SOD. Exposure to FP diminishes all evaluated antioxidant genes. It could fulfilled that supplementation with βG successfully alleviated the immune-toxic and antioxidant impact of FP in tilapias.
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Source |
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http://dx.doi.org/10.1016/j.fsi.2019.09.033 | DOI Listing |
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