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Immune-protective, antioxidant and relative genes expression impacts of β-glucan against fipronil toxicity in Nile tilapia, Oreochromis niloticus. | LitMetric

Immune-protective, antioxidant and relative genes expression impacts of β-glucan against fipronil toxicity in Nile tilapia, Oreochromis niloticus.

Fish Shellfish Immunol

Department of Biochemistry, Faculty of Veterinary Medicine, Zagazig University, Egypt; Department of Biochemistry, Faculty of Science, University of Jeddah, Jeddah, Saudi Arabia.

Published: November 2019

Our study is considered to attempt reducing the immune-toxic and antioxidant impacts of exposure to fipronil (FP) on Nile tilapia, Oreochromis niloticus using the β-glucan (βG). Two hundred and seventy fingerlings of Nile tilapia were divided randomly into six groups (45 tilapias of each, in 3 replicates): group I control (CT) group nourished on a basal diet. Group II (βG) nourished a basal diet supplemented with 0.4% βG. Groups III (1/20 FP) and V (1/10 FP) was exposed to 1/20 and 1/10 of the 96 h LC of FP in water and nourished the basal diet respectively. Groups IV (1/20 FP+ βG) and VI (1/10 FP+ βG) were exposed to 1/20 and 1/10 FP concomitantly with 0.4% βG supplementation for 90 successive days. Growth performance metrics were higher in βG group than CT. While those metrics were fallen at exposure to 1/20 or 1/10 FP. Supplementation with βG elevated the IgM and lysozyme levels.Whereas, tilapias exposed to FP only at different concentration showed lowering of those compared to CT. Supplementation with βG was effectively augmented IgM and lysozyme in 1/20 FP exposed tilapias. Furthermore, in a minor grade at 1/10 FP exposed tilapias. Exposure to FP increased the activities of hepatic markers chiefly at 1/10, however the βG supplementation was successfully improved these markers. There was imbalance of cortisol level at FP exposure where, βG combining to FP alleviate this disparity. There was fallen in LDH, MDH and FDPase in βG tilapias where continuing raise in 1/10 FP followed by 1/20 FP. βG supplementation raise the level of GSH, without significant variations in MDA conversely occurs in FP alone. Genes expression of βG caused raise of both GPx and GR, without fluctuations in CAT and SOD. Exposure to FP diminishes all evaluated antioxidant genes. It could fulfilled that supplementation with βG successfully alleviated the immune-toxic and antioxidant impact of FP in tilapias.

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Source
http://dx.doi.org/10.1016/j.fsi.2019.09.033DOI Listing

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