A one-pot iron-catalyzed conversion of allylic alcohols to α-methyl ketones has been developed. This isomerization-methylation strategy utilized a (cyclopentadienone)iron(0) carbonyl complex as precatalyst and methanol as the C1 source. A diverse range of allylic alcohols undergoes isomerization-methylation to form α-methyl ketones in good isolated yields (up to 84% isolated yield).
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007281 | PMC |
| http://dx.doi.org/10.1021/acs.orglett.9b02900 | DOI Listing |
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