In recent years, the quality of germinal cells has been recognized as the main factor determining reproductive potential. Standard sperm analysis is of limited value for predicting both the achievement of a pregnancy and the outcomes of assisted reproductive technologies, which raises the question of the additional significance of functional testing. Most current guidelines recommend to perform additional studies from a scientific point of view, recognizing their importance, but dont include men in the basic diagnostic schemes. In this review, we try to discuss of the relevance of special sperm testing.
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Commun Med (Lond)
January 2025
Patient-Led Research Collaborative, Oakland, CA, USA.
Background: Prior case series suggest that a 5-day course of oral Paxlovid (nirmatrelvir/ritonavir) benefits some people with Long COVID, within and/or outside of the context of an acute reinfection. To the best of our knowledge, there have been no prior case series of people with Long COVID who have attempted longer courses of nirmatrelvir/ritonavir.
Methods: We documented a case series of 13 individuals with Long COVID who initiated extended courses (>5 days; range: 7.
J Am Pharm Assoc (2003)
January 2025
Arizona Department of Health Services, Phoenix, AZ, USA. Electronic address:
Background: Pharmacist-provided Medication Therapy Management (MTM) services have demonstrated improved clinical outcomes for patients. MTM services could incorporate additional lifestyle and wellness counseling to potentially enhance healthcare for underserved patients.
Objective: To report the outcomes of a new pharmacist-provided MTM lifestyle and wellness counseling program for underserved rural Arizonans with diabetes and/or hypertension.
Front Pharmacol
December 2024
Charité - Universitätsmedizin Berlin, Institute of Clinical Pharmacology and Toxicology, Berlin, Germany.
Chief executives have been educated and trained how to handle business, to take executive decisions, and take care of financial and human resources in favor of the company they are leading. CEOs (chief executive officers) of innovative pharmaceutical businesses, among others, have only seldomly been trained to understand the immense time periods involved between decisions and their moment of impact, and the skills and languages used by their internal and external R&D (research and development) staff. R&D staff and regulators, however, have undergone full training, and are usually capable of understanding each other across their various specialties (among them compound finding, quality, safety, efficacy, efficiency, risk assessment and management).
View Article and Find Full Text PDFHeliyon
December 2024
Centre for Settlements Studies, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Galamsey is a Ghanaian jargon from the phrase "gather and sell," coined from how gold was mined with simple tools by natives and sold afterwards. Despite its socio-economic benefits, a significant upsurge in galamsey has been widely associated with significant environmental impacts viz, destruction of aquatic ecosystems and ecosystems services. This paper discuses impacts of galamsey on aquatic ecosystems and ecosystem services using the Driver-Pressure-State-Impact-Response framework in combination with the quantitative defensible impact characterization approach to establish the cause-and-impact relationships between pollutants associated with galamsey, the extent to which aquatic ecosystems and ecosystem services are impacted while answering the questions what is happening to the environment and why it is happening (compilation and analysis of status and trends of key environmental indicators) and what the consequences are for the environment (analysis of impacts of environmental change on ecosystem services).
View Article and Find Full Text PDFGeburtshilfe Frauenheilkd
January 2025
Department of Obstetrics and Gynaecology, Erlangen University Hospital, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Introduction: Preconception obesity is a risk factor for pregnancy and delivery, which is why giving birth in a perinatal center (care levels I and II) is recommended. There are currently no studies which have investigated the birth outcomes of obese patients based on the care level of the maternity hospital. This study aims to assess the effect of a higher body mass index prior to conception on maternal and fetal outcomes in a maternity hospital (care level IV).
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