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Comparative Proteome Analysis of Epicardial and Subcutaneous Adipose Tissues from Patients with or without Coronary Artery Disease. | LitMetric

AI Article Synopsis

  • The study investigates the proteome differences between epicardial adipose tissue (EAT) and subcutaneous adipose tissue (SAT) in patients with and without coronary artery disease (CAD).
  • The researchers collected tissue samples from 6 CAD and 6 non-CAD patients and used advanced techniques (iTRAQ and LC-MS/MS) to identify proteins expressed in these tissues.
  • The results revealed 385 differentially expressed proteins in EAT and 210 in SAT related to CAD, with notable proteins linked to disease processes like inflammation and lipid metabolism, highlighting the potential roles of mitochondrial dysfunction and LXR/RXR activation in CAD.

Article Abstract

Background And Aims: Owing to its unique anatomical structure and metabolism, epicardial adipose tissue (EAT) has attracted amount of attention in coronary artery disease (CAD) research. Here, we analyzed differences in proteome composition in epicardial (EAT) and subcutaneous adipose tissues (SAT) from patients with or without CAD.

Methods: EAT and SAT samples were collected from 6 CAD patients and 6 non-CAD patients. Isobaric Tagging for Relative and Absolute Quantitation (iTRAQ) analysis combined with liquid chromatography tandem-mass spectrometry (LC-MS/MS) was performed to identify the differentially expressed proteins.

Results: In total, 2348 proteins expressed in EAT and 2347 proteins expressed in SAT were separately identified. 385 differentially expressed proteins were found in EAT and 210 proteins were found in SAT in CAD patients compared to non-CAD patients. Many proteins differentially expressed in EAT of CAD patients were involved in biological functions associated with CAD development such as cell-to-cell signaling and interaction, inflammatory response, and lipid metabolism. Differential expressions of proteins (MMP9, S100A9, and clusterin) in EAT or SAT were involved in several signaling pathways such as mitochondrial dysfunction, acute phase inflammation, and LXR/RXR activation, which was confirmed by western blotting, and similar results were obtained.

Conclusions: The largest profiles of differentially expressed proteins in EAT and SAT between CAD patients and non-CAD patients were identified. The significant signal pathways, mitochondrial dysfunction, and LXR/RXR activation, which differential proteins were involved in, were firstly found to play roles in EAT of CAD patients, and clusterin was firstly found to be upregulated in EAT of CAD patients.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732630PMC
http://dx.doi.org/10.1155/2019/6976712DOI Listing

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