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Exploring force-driven stochastic folding dynamics in mechano-responsive proteins and implications in phenotypic variation.
Nat Commun
January 2025
Department of Chemical Sciences, Indian Institute of Science Education and Research Mohali, Punjab, India.
Single-point mutations are pivotal in molecular zoology, shaping functions and influencing genetic diversity and evolution. Here we study three such genetic variants of a mechano-responsive protein, cadherin-23, that uphold the structural integrity of the protein, but showcase distinct genotypes and phenotypes. The variants exhibit subtle differences in transient intra-domain interactions, which in turn affect the anti-correlated motions among the constituent β-strands.
View Article and Find Full Text PDFResearch on Sensitivity Improvement Methods for RTD Fluxgates Based on Feedback-Driven Stochastic Resonance with PSO.
Sensors (Basel)
January 2025
College of Computer Science and Technology, Beihua University, No. 3999 East Binjiang Road, Jilin 132013, China.
With the wide application of Residence Time Difference (RTD) fluxgate sensors in Unmanned Aerial Vehicle (UAV) aeromagnetic measurements, the requirements for their measurement accuracy are increasing. The core characteristics of the RTD fluxgate sensor limit its sensitivity; the high-permeability soft magnetic core is especially easily interfered with by the input noise. In this paper, based on the study of the excitation signal and input noise characteristics, the stochastic resonance is proposed to be realized by adding feedback by taking advantage of the high hysteresis loop rectangular ratio, low coercivity and bistability characteristics of the soft magnetic material core.
View Article and Find Full Text PDFA novel micromagnetic carrier-modified integrated fixed-film activated sludge system for simultaneous efficient removal of tetracycline and mitigation of antibiotic resistance genes proliferation and dissemination.
Water Res
January 2025
State Key Laboratory of Pollution Control and Resource Reuse, School of Environment, Nanjing University, Nanjing, Jiangsu 210023, China. Electronic address:
To address the challenge of antibiotic-containing wastewater, a novel micromagnetic carrier-modified integrated fixed-film activated sludge system (MC-IFAS) was developed for treating tetracycline (TC)-containing swine wastewater in this study. The magnetic effects of the MC significantly enhanced TC removal by improving TC biosorption and biodegradation in both the suspended activated sludge and the carrier-attached biofilm in the MC-IFAS. The increased electrostatic attraction and number of binding sites in both the activated sludge and the biofilm enhanced their TC biosorption capacities, particularly in the activated sludge.
View Article and Find Full Text PDFTernary stochastic neuron - implemented with a single strained magnetostrictive nanomagnet.
Nanotechnology
January 2025
Department of Electrical and Computer Engineering, Virginia Commonwealth University, 601 W. Main Street, Richmond, VA 23284, USA, Richmond, 23284, UNITED STATES.
Stochastic neurons are extremely efficient hardware for solving a large class of problems and usually come in two varieties - "binary" where the neuronal state varies randomly between two values of ±1 and "analog" where the neuronal state can randomly assume any value between -1 and +1. Both have their uses in neuromorphic computing and both can be implemented with low- or zero-energy-barrier nanomagnets whose random magnetization orientations in the presence of thermal noise encode the binary or analog state variables. In between these two classes is n-ary stochastic neurons, mainly ternary stochastic neurons (TSN) whose state randomly assumes one of three values (-1, 0, +1), which have proved to be efficient in pattern classification tasks such as recognizing handwritten digits from the MNIST data set or patterns from the CIFAR-10 data set.
View Article and Find Full Text PDFQuantitative peripheral live single T-cell dynamic polyfunctionality profiling predicts lung cancer checkpoint immunotherapy treatment response and clinical outcomes.
Transl Lung Cancer Res
December 2024
Penn State Cancer Institute, Penn State Health Milton S. Hershey Medical Center, Penn State College of Medicine, Penn State University, Hershey, PA, USA.
Background: Predictive biomarkers for immune checkpoint inhibitors (ICIs), e.g., programmed death ligand-1 (PD-L1) tumor proportional score (TPS), remain limited in clinical applications.
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