[The dysfunction of endothelium and humoral mediators of blood plasma in patients with ulcerous colitis.].

The study was carried out to evaluate biological reaction of endothelium-depended vasodilation and disorder of its regulation by humoral mediators of inflammation in patients with ulcerous colitis. And also to compare disorders of function of endothelium with content of cytokines in blood plasma and severity of inflammation in intestine. The examined sampling consisted of 90 patients with diagnosis of ulcerous colitis at the phase of exacerbation of disease. The concentration of humoral mediators of inflammation was established: tumor necrosis factor-alpha, interleukins-6 and -4, monocyte chemo-attractant protein-1. The content of endothelium growth factor of vessels in blood serum was determined as a marker of damage of endothelium. The functional condition of endothelium of vessels was evaluated on the basis of photoplethysmography and software support Pulsware (Samara). In case of ulcerous colitis hyper-secretion of humoral mediators of inflammation was established in blood serum: tumor necrosis factor-alpha, interleukins-6, monocyte chemo-attractant protein-1. The median of concentration of endothelium growth factor of vessels thrice exceeded the level specific for control group of healthy individuals. The disorder of biological reaction of endothelium-depended vasodilation was established in 95% of patients with ulcerous colitis. The reliable correlation relationship between concentration of humoral mediator of inflammation, endothelium growth factor of vessels and severity of destructive alterations in large intestine wall. The combination of disorders of humoral regulation of biological reaction of endothelium-depended vasodilation and markers of dysfunction of endothelium reflects activity of local destruction of tissue. The severity of clinical manifestation of ulcerous colitis substantiates functional interaction of inflammation reaction and angiogenesis. The detection of humoral mediators of inflammation and endothelium growth factor of vessels is reasonably to implement as non-invasive techniques of evaluation of severity of inflammation in wall of large intestine under ulcerous colitis.