Stable while reactive isatin-derived saturated esters have been utilized as 3-carbon synthons in a base-promoted formal [3 + 2] annulation with N-Boc imines. The developed protocol offers a direct pathway for the rapid and divergent construction of two classes of 3,3'-spirooxindole γ-butyrolactam skeletons that are recognized as the privileged structures of various bioactive compounds. This protocol also has the advantages of mild reaction conditions, scalability and wide reaction scope.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/c9ob01347d | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Application of isatin-derived saturated esters in the synthesis of 3,3'-spirooxindole γ-butyrolactams.
Org Biomol Chem
October 2019
State Key Laboratory of Natural Medicines, School of Science, China Pharmaceutical University, Nanjing, 210009, P. R. China.
Stable while reactive isatin-derived saturated esters have been utilized as 3-carbon synthons in a base-promoted formal [3 + 2] annulation with N-Boc imines. The developed protocol offers a direct pathway for the rapid and divergent construction of two classes of 3,3'-spirooxindole γ-butyrolactam skeletons that are recognized as the privileged structures of various bioactive compounds. This protocol also has the advantages of mild reaction conditions, scalability and wide reaction scope.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!