A one-pot method for joining three separate components leading to an assortment of N-substituted 3,4-dihydro-2-1,3-benzoxazines is described. The method involves the addition of a Grignard reagent to an -OBoc salicylaldehyde in the presence of an imine. With a variety of components, 15 examples are presented, including the diastereoselective incorporation of chiral imines.
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| http://dx.doi.org/10.1021/acs.orglett.9b02655 | DOI Listing |
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