The intestinal epithelium is derived from intestinal stem cells (ISCs) and has direct contact with nutrients and toxins. However, whether methionine (Met) or a methionine hydroxyl analogue (2-hydroxy-4-(methylthio)butanoic acid (HMB)) can alleviate deoxynivalenol (DON)-induced intestinal injury remains unknown. Mice were treated orally with Met or HMB on days 1-11 and with DON on days 4-8. On day 12, the mice were sacrificed, and the jejunum was collected for crypt isolation and culture. Mouse enteroids were treated with DON and Met or HMB ex vivo. The results showed that Met and HMB increased the average daily feed intake and average daily gain of the mice. Met and HMB also improved the jejunal structure and barrier integrity and promoted ISC expansion, as indicated by the increased enteroid formation efficiency and area, under DON-induced injury conditions. In addition, DON-induced decreases in ISC activity were rescued Wnt/β-catenin signaling reactivation by Met or HMB in vivo and ex vivo. Collectively, our findings reveal that Met and HMB alleviated DON-induced intestinal injury by improving ISC expansion and reactivating Wnt/β-catenin signaling. Our study thus provides a nutritional intervention for intestinal diseases involving Wnt/β-catenin signaling.
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http://dx.doi.org/10.1021/acs.jafc.9b04442 | DOI Listing |
J Affect Disord
March 2025
Body-Brain-Mind Laboratory, School of psychology, Shenzhen University, 518060, China. Electronic address:
Background: The independent associations of physical activity (PA), sleep duration (SL), and screen time (ST) with health outcome measures have been well-documented among children and adolescents, but not in youth with moderate/severe ADHD. To this end, the present study aimed to investigate the associations between three components within 24-hour movement behaviour (24-HMB) framework and core symptoms and school engagement in youth with moderate/severe ADHD.
Methods: This study used pooled data from the 2021-2022 U.
Healthcare (Basel)
October 2024
Faculty of Sports Science, Sendai University, Shibata 9891693, Japan.
Background: Adherence to the World Health Organization's 24-hour movement behavior (24-HMB) guidelines is associated with various health outcomes. However, its relationship with bone mineral density (BMD) in young children has not been investigated. This study aimed to examine the cross-sectional and longitudinal associations between adherence to the 24-HMB guidelines and BMD in young children.
View Article and Find Full Text PDFGinekol Pol
October 2024
Chair and Department of Gynecology, Obstetrics and Gynecological Oncology, Pediatric and Adolescent Gynecology. Medical University of Silesia, Katowice, Poland., Poland.
BMC Public Health
September 2024
Department of Spine Surgery, the Fist Affiliated Hospital of Shenzhen University, Number 3002, Sungang west road, Futian district, Shenzhen, 518035, China.
Complement Ther Clin Pract
November 2024
Body-Brain-Mind Laboratory, School of Physical Education, School of Psychology, Shenzhen University, Shenzhen, 518060, China. Electronic address:
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