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Deciphering the fate of replication-induced DNA double-strand breaks.
Mol Cell
January 2025
Department of Biochemistry & Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
In this issue of Molecular Cell, studies by Xu et al., Kimble et al., and Elango et al.
View Article and Find Full Text PDFSafety of Low-Dose Quetiapine for Insomnia in Older Adults.
Drugs Aging
January 2025
Pharmacy Outcomes Research Group, Kaiser Permanente, 12254 Bellflower Blvd, Downey, CA, 90242, USA.
Background And Objective: Quetiapine is a Food and Drug Administration (FDA) approved second-generation antipsychotic. It is also commonly used at low dose for its sedative properties to treat insomnia in the older population. Quetiapine at standard doses has been associated with increased risk of cerebrovascular events, cognitive decline, and mortality in patients with dementia, especially within older adults.
View Article and Find Full Text PDFThe social welfare effect of e-commerce product reputation information asymmetry from the perspective of network externality.
PLoS One
January 2025
Business School, Shandong Normal University, Jinan, China.
Reputation is the most important intangible asset of merchants. In the e-commerce platform market, reputation information has become an important signal of product quality. However, with increasingly fierce competition among merchants on these platforms, violations of reputation information, such as "click farming," "cash rebate for favorable comments," and "pay per click," have caused information asymmetry and adverse selection.
View Article and Find Full Text PDFInherited genome instability.
Science
January 2025
Spanish National Cancer Research Center (CNIO), Madrid, Spain.
Germline structural variants are a risk factor for pediatric extracranial solid tumors.
View Article and Find Full Text PDFSingle-Cell Lineage Tracing and Clonal State-Fate Analysis.
Methods Mol Biol
January 2025
Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Catalonia, Spain.
Lineage tracing has significantly advanced our comprehension in many areas of biology, such as development or immunity, by precisely measuring cellular processes like migration, division, or differentiation across labeled cells and their progeny. Traditional recombinase-based prospective lineage tracing is limited by the need for a priori cell type information and is constrained in the numbers of clones it can simultaneously track. In this sense, clonal lineage tracing with integrated random barcodes offers a robust alternative, enabling researchers to label and track a vast array of cells and their progeny over time.
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