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The impact of different treatments on thromboelastography and other conventional parameters in patients with colorectal cancer.
Discov Oncol
December 2024
Department of Oncology, Jiangsu Province Hospital of Chinese Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, Jiangsu, China.
Objective: To comprehend the effects of diverse therapeutic interventions on thromboelastography (TEG) and conventional coagulation parameters among individuals diagnosed with colorectal cancer, this study aims to explore the clinical relevance of both thromboelastography and conventional coagulation metrics in evaluating coagulation function and predicting the incidence of thrombotic and hemorrhagic events in patients with colorectal cancer.
Methods: A cohort of 122 patients with colorectal cancer retrospectively recruited and divided into 2 groups: those undergoing surgical intervention (operation group) and those not subjected to surgery (non-operation group). According to the different types of treatment they received, the operation group was divided into chemotherapy-only group and a group receiving a combination of targeted therapy and chemotherapy.
Refining Ounce-Equivalents Using the EAA-9 Approach for Protein Scoring and Dietary Guidance.
J Acad Nutr Diet
November 2024
Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, Illinois.
Background: The US Department of Agriculture (USDA) Protein Food ounce-equivalents are designed to identify plant sources of protein foods and provide serving size substitutions. Although the ounce-equivalent concept is simple, it fails to generate equivalent exchanges for protein or essential amino acids (EAAs).
Objective: To accurately define the EAA content of USDA Protein Food ounce-equivalents, to develop a more accurate food exchange list, and to evaluate the EAA-9 protein quality framework as a tool for determining precise EAA-equivalent substitutions.
Radiomics Feature Stability in True and Virtual Non-Contrast Reconstructions from Cardiac Photon-Counting Detector CT Datasets.
Diagnostics (Basel)
November 2024
Department of Diagnostic and Interventional Radiology, University Hospital Augsburg, Stenglinstr. 2, 86156 Augsburg, Germany.
: Virtual non-contrast (VNC) series reconstructed from contrast-enhanced cardiac scans acquired with photon counting detector CT (PCD-CT) systems have the potential to replace true non-contrast (TNC) series. However, a quantitative comparison of the image characteristics of TNC and VNC data is necessary to determine to what extent they are interchangeable. This work quantitatively evaluates the image similarity between VNC and TNC reconstructions by measuring the stability of multi-class radiomics features extracted in intra-patient TNC and VNC reconstructions.
View Article and Find Full Text PDFPossibilities and Limitations in Substituting anti-Drug Antibody Titers with Signal-to-Noise Ratios: A Comprehensive Comparison Using Two Clinical Trial Datasets of Adalimumab.
AAPS J
November 2024
Clinical Bioanalysis Group, Samsung Bioepis Co., Ltd, 76, Songdogyoyuk-ro, Yeonsu-gu, Incheon, 21987, Republic of Korea.
Immunogenicity assessment is vital in clinical trials and is measured through a multi-tiered approach (screening, confirmatory and titer assays). However, recent studies have suggested that titer results could be reported from ADA signal-to-noise ratios (S/N ratios=sample mean signal/negative control mean signal). More data analysis using two clinical trials of adalimumab: SB5-1003 (single-dose, healthy participants) and SB5-4001 (multiple-dose, interchangeability study, patients with plaque psoriasis), therefore, is indispensable whether substituting ADA S/N ratio as an alternative way of reporting titer results has no impact on interpretation on clinical outcome.
View Article and Find Full Text PDFMetabolomic profiling and 16 S rRNA metabarcoding of endophytes of two Aloe species revealed diverse metabolites.
AMB Express
November 2024
Unit of Environmental Sciences and Management, North-West University, Potchefstroom, 2520, South Africa.
Aloe species are often used interchangeably for medicinal and cosmeceutical applications, presenting a challenge to the biological efficacy consistency of some herbal preparations. Sustainable production of high-quality commonly used medicinal plants remains a limitation for commercialisation. Thus, this study investigated the potential for plant substitution by examining bacterial endophytes capable of producing similar host plant secondary metabolites.
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