Purpose: In the last years, some studies investigated dosimetric benefits of a free flattening filter for the photon mode in the radiotherapy field. This study aims to provide a theoretical study published and analysis of basic dosimetric properties for a Saturne 43 Linac head to implement free flattening filter beams clinically.
Material And Methods: This is the first Monte Carlo study for the head of Saturne 43 with replacement flattening filter mode investigating beam dosimetric characteristics, including central axis absorbed doses, beam profiles and photon energy spectra. The later ones were analyzed for flattening filter and replacement flattening filter beams using BEAMnrc and DOSXYZnrc Monte Carlo codes for 10 × 10 cm, 5 × 5 cm and 2 × 2 cm square field sizes.
Results: A 3.94-fold increase of dose rate and electron contaminating increased by 246.4 % with the replacement flattening filter mode for field size of 10 × 10 cm. Reduction was made by replacement flattening filter beam in the peripheral dose up to 30%, and the time was reduced more than 50 %.
Conclusion: Results obtained from our study revealed that some characteristic dosimetries such as the maximum increase in depth dose rate, decrease in out-of-depth dose, and reducing time can be beneficial for the unflattened beam to be used in the radiotherapy for the advanced techniques.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709350 | PMC |
http://dx.doi.org/10.31661/jbpe.v0i0.924 | DOI Listing |
Med Phys
January 2025
Institut Curie, Université PSL, CNRS UMR3347, Inserm U1021, Signalisation Radiobiologie et Cancer, Orsay, France.
Background: Breast cancer is the leading cause of female cancer mortality worldwide, accounting for 1 in 6 cancer deaths. Surgery, radiation, and systemic therapy are the three pillars of breast cancer treatment, with several strategies developed to combine them. The association of preoperative radiotherapy with immunotherapy may improve breast cancer tumor control by exploiting the tumor radio-induced immune priming.
View Article and Find Full Text PDFMed Dosim
January 2025
Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA.
Most of conventional 2-dimensional (2D) methods verify dose of multiple targets separately one-by-one for Single-isocenter Multiple-target (SIMT) brain plans, which are inefficient and sub-optimal. This study presented a practical method to verify the dose of 2 targets simultaneously for improved efficiency and accuracy. Fifteen Stereotactic Radiation Therapy (SRT) and sixteen Stereotactic Radiosurgery (SRS) plans were used for this study.
View Article and Find Full Text PDFRadiat Environ Biophys
January 2025
Radiation Physics, Faculty of Science, Al -Azhar University, Cairo, Egypt.
This study aimed to evaluate the dosimetric and clinical outcomes of flattening filter (FF) versus flattening filter-free (FFF) beams in head and neck cancer (HNC) patients treated with volumetric modulated arc therapy (VMAT). Twenty-four patients with 70/59.4/54 Gy dose prescribed in 33 fractions with simultaneous integrated boost treatment were retrospectively analyzed to compare treatment delivery efficiency, target coverage, sparing of organs at risk (OARs), and remaining volume at risk (RVR) in two HNC groups (nasopharyngeal and oropharyngeal).
View Article and Find Full Text PDFBiomed Phys Eng Express
January 2025
Department of Physics, Mindanao State University-Iligan Institute of Technology, Iligan City, 9200, Philippines.
. To accurately model and validate the 6 MV Elekta Compact linear accelerator using the Geant4 Application for Tomographic Emission (GATE). In particular, this study focuses on the precise calibration and validation of critical parameters, including jaw collimator positioning, electron source nominal energy, flattening filter geometry, and electron source spot size, which are often not provided in technical documentation.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Department of Ecology and Evolutionary Biology, University of Kansas, Lawrence, KS 66045.
Climate change is increasing the frequency of large-scale, extreme environmental events and flattening environmental gradients. Whether such changes will cause spatially synchronous, large-scale population declines depends on mechanisms that limit metapopulation synchrony, thereby promoting rescue effects and stability. Using long-term data and empirical dynamic models, we quantified spatial heterogeneity in density dependence, spatial heterogeneity in environmental responses, and environmental gradients to assess their role in inhibiting synchrony across 36 marine fish and invertebrate species.
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